{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:19:43Z","timestamp":1773098383322,"version":"3.50.1"},"reference-count":89,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Mitral regurgitation (MR) is common in patients undergoing transcatheter aortic valve replacement (TAVR). However, it is unclear how MR severity affects prognosis. This meta\u2010analysis evaluated the associations among baseline MR severity, cardiovascular outcomes, and mortality after TAVR. Eligible studies included adult patients undergoing TAVR with stratified MR severity (MR\u2009\u2265\u20092 or MR\u2009\u2265\u20093) and reported the post\u2010TAVR clinical outcomes. Sensitivity analyses stratified by follow\u2010up duration, leave\u2010one\u2010out sensitivity, and meta\u2010regression were also conducted. Forty\u2010two studies (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u200967,257 patients) were included. MR\u2009\u2265\u20092 was associated with increased all\u2010cause mortality during follow\u2010up (&gt;\u200930 days) (hazard ratio [HR]: 1.40; 95% confidence interval [CI]: 1.26, 1.55) and cardiovascular mortality (risk ratio [RR]: 1.80; 95% CI: 1.05, 3.08), but not with stroke, transient ischemic attack, myocardial infarction (MI), or heart failure hospitalization. MR\u2009\u2265\u20093 conferred an even higher risk of all\u2010cause mortality during follow\u2010up (RR: 1.55; 95% CI: 1.24, 1.94) and rehospitalization (RR: 1.40; 95% CI: 1.17, 1.67), but not for stroke and MI. MR improvement occurred in 41% of patients within &lt;\u20091\u2010year post\u2010TAVR, declined to 15% at &gt;\u20091\u2010year post\u2010TAVR. Baseline moderate\u2010to\u2010severe MR (MR\u2009\u2265\u20092) predicts all\u2010cause mortality during follow\u2010up and cardiovascular mortality after TAVR, particularly severe MR (MR\u2009\u2265\u20093). While no consistent associations were found with nonfatal outcomes such as stroke, TIA, MI, or heart failure hospitalization, the prognostic impact of MR appears to be predominantly mortality\u2010centered.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70386","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T11:41:20Z","timestamp":1764502880000},"page":"577-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Concomitant Mitral Regurgitation on Cardiovascular Events and Mortality After Transcatheter Aortic Valve Replacement: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-0061","authenticated-orcid":false,"given":"Bahar","family":"Darouei","sequence":"first","affiliation":[{"name":"Isfahan Cardiovascular Research Center Cardiovascular Research Institute Isfahan 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