{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:20:07Z","timestamp":1773098407369,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A minimalist approach to transcatheter aortic valve replacement (TAVR) has accompanied the increase in TAVR procedures worldwide. Comprehensive evidence regarding the safety of non\u2010anesthetist\u2010led conscious sedation for TAVR is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to evaluate the outcomes of patients undergoing TAVR with non\u2010anesthetist\u2010led conscious sedation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis included consecutive patients who underwent percutaneous transfemoral TAVR with non\u2010anesthetist\u2010led conscious sedation, from March 2018 to 2025, in a single high\u2010volume center. Thirty\u2010day outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 2854 patients who underwent TAVR, 2000 (70.1%) had non\u2010anesthetist\u2010led conscious sedation (age: 80.7\u2009\u00b1\u20096.5 years, 42.1% female). The annual proportion of non\u2010anesthetist\u2010led conscious sedation procedures increased from 37% (2018\u20132019) to 81% (2024\u20132025). Fentanyl was administered to 1986 (99.3%) patients (median: 75\u2009mcg [IQR: 50\u2013100]) and Midazolam to 945 (47.3%) patients (median: 1.5\u2009mg [IQR: 1.0\u20132.0]). Mean procedural duration was 81.3\u2009\u00b1\u200967.7\u2009min. Emergency anesthetic support was required for 53 (2.7%) patients, due to: vascular access complications (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915), cardiac arrest (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), annular rupture\/aortic dissection (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), profound hypotension (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), agitation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), ventricular perforation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) and reduced consciousness (stroke) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). Conversion to general anesthesia was required for 24 (1.2%) patients. Emergency bail\u2010out surgery (cardiac\/vascular) was undertaken in 15 patients (0.75%). Among the 2000 patients, 30\u2010day mortality was 1.3%, and VARC\u20103 technical success, device success, and early safety were achieved in 97.2%, 92.7%, and 78.9% of patients, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010anesthetist\u2010led conscious sedation can be delivered safely in most patients undergoing percutaneous transfemoral TAVR. The need for emergency anesthetic support is low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70392","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T06:13:20Z","timestamp":1764742400000},"page":"639-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Non\u2010Anesthetist Led Conscious Sedation for 2000 Transcatheter Aortic Valve Implantations"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-5153","authenticated-orcid":false,"given":"Annette","family":"Maznyczka","sequence":"first","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sacchin","family":"Arockiam","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca Parker","family":"North","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cunnington","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Malkin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Blackman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-4451","authenticated-orcid":false,"given":"Noman","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405880"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.03.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307447"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae043"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.123.013104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0976-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-01197"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.12.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00096"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2017.08.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.07.078"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.122.012168"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-025-02654-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2025.01.324"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2020.1773591"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjca.2022.0089"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.154"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14210"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.038"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew335"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1099959"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"issue":"9","key":"e_1_2_8_24_1","first-page":"1518","article-title":"Sedation or General Anesthesia for Transcatheter Aortic Valve Implantation (TAVI)","volume":"7","author":"Mayr N. P.","year":"2015","journal-title":"Journal of Thoracic Disease"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:49:43Z","timestamp":1773060583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccd.70392"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70392","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}