{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:32:40Z","timestamp":1786559560189,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intermediate\u2010high risk acute pulmonary embolism (PE) carries a significant long\u2010term burden of post\u2010thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (CTEPH). Standard anticoagulation does not actively resolve obstructive thrombi, and systemic thrombolysis is limited by high bleeding risk. While percutaneous mechanical thrombectomy (PMT) offers rapid thrombus removal, robust multicenter evidence regarding its efficacy in preventing long\u2010term complications is scarce, leading to its current class IIb recommendation in major international guidelines (2022 ESC, 2024 AHA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the long\u2010term complications, right heart function, and quality of life between patients with intermediate\u2010high risk acute pulmonary embolism treated with 8 F catheter percutaneous mechanical thrombectomy plus anticoagulation versus anticoagulation alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study sought to evaluate whether 8\u2009F catheter simple aspiration PMT combined with standard anticoagulation, compared to anticoagulation alone, improves long\u2010term outcomes\u2014including PTS, CTEPH, right heart function, and quality of life\u2014in patients with intermediate\u2010high risk acute PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this multicenter, retrospective cohort study, we enrolled 426 patients with intermediate\u2010high risk acute PE from 10 regional tertiary centers (2019\u20132023). After 1:1 propensity score matching (PSM) to balance baseline characteristics, patients were allocated into a PMT plus anticoagulation group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009182) and an anticoagulation\u2010alone group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009244). Primary endpoints were the incidence of PTS at 12 months (diagnosed via modified Villalta scale) and CTEPH at 24 months (confirmed by right heart catheterization). Secondary endpoints included right ventricular ejection fraction (RVEF), SF\u201036 quality of life scores, and adverse events (all\u2010cause mortality, PE recurrence, major bleeding) at 24 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After a median follow\u2010up of 24 months, the PMT group demonstrated significantly lower incidences of 12\u2010month PTS (15.2% vs. 34.8%; adjusted HR\u2009=\u20090.32, 95% CI: 0.19\u20130.54;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 24\u2010month CTEPH (1.3% vs. 5.6%; adjusted HR\u2009=\u20090.25, 95% CI: 0.11\u20130.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The PMT group also exhibited superior improvement in RVEF at 24 months (from baseline 36.2%\u2009\u00b1\u20095.7% to 58.2%\u2009\u00b1\u20096.3% in the PMT group vs. from baseline 35.8%\u2009\u00b1\u20096.1% to 46.3%\u2009\u00b1\u20096.1% in the control group; between\u2010group\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and all core domains of the SF\u201036 at 24 months (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Critically, the two groups had comparable rates of all\u2010cause mortality (2.7% vs. 3.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.518), PE recurrence (2.2% vs. 2.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.632), and major bleeding (3.3% vs. 2.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.806).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with intermediate\u2010high risk acute PE, 8\u2009F catheter PMT combined with anticoagulation significantly reduces the risks of PTS and CTEPH, enhances right ventricular recovery, and improves quality of life, without increasing adverse events. These compelling real\u2010world findings challenge the current guideline positioning (e.g., 2022 ESC, 2024 AHA) that classifies PMT as a class IIb rescue therapy and strongly support its consideration as a first\u2010line treatment strategy for this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70403","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:05:34Z","timestamp":1765173934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RETRACTED: 8\u2009F Catheter Percutaneous Mechanical Thrombectomy Plus Anticoagulation Versus Anticoagulation Alone in Intermediate\u2010High Risk Acute Pulmonary Embolism: A Multicenter Real\u2010World Study on Long\u2010Term Complications, Right Heart Function, and Quality of Life"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9326-0142","authenticated-orcid":false,"given":"Peng","family":"Yuan","sequence":"first","affiliation":[{"name":"Interventional Department, Affiliated Jianhu Hospital of Xinglin College Nantong University Yancheng Jiangsu China"},{"name":"Jianhu Clinical Medical College of Yangzhou University Yancheng Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwen","family":"Shen","sequence":"additional","affiliation":[{"name":"Interventional Department, Affiliated Jianhu Hospital of Xinglin College Nantong University Yancheng Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajing","family":"Chen","sequence":"additional","affiliation":[{"name":"Interventional Department, Affiliated Jianhu Hospital of Xinglin College Nantong University Yancheng Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Surgery Affiliated Hospital of Nantong University Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanjing Zhongda Hospital Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianchen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Surgery Suzhou Municipal Hospital Affiliated to Soochow University Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongqing","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Huai'an Hospital of Huai'an City Huai'an Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Zhenjiang First People's Hospital Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu'an","family":"Wang","sequence":"additional","affiliation":[{"name":"Interventional Department Affiliated Subei People's Hospital of Yangzhou University Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Yancheng First People's Hospital Yancheng Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Interventional Department Yancheng Third Hospital Yancheng Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Surgery Suzhou Municipal Hospital Affiliated to Soochow University Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Surgery Nanjing First Hospital Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"4156","article-title":"2022 ESC Guidelines for the Diagnosis and Management of Acute Pulmonary Embolism","volume":"43","author":"Konstantinides S. 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A Clinical Consensus Statement on Behalf of the European Reference Network on Rare Respiratory Diseases","volume":"32","author":"Kim N. H.","year":"2023","journal-title":"European Respiratory Review"},{"key":"e_1_2_13_10_1","first-page":"581","article-title":"The Management and Outcomes of Acute Venous Thromboembolism in China: A Prospective Multicenter Registry","volume":"160","author":"Zhai Z.","year":"2021","journal-title":"Chest"},{"key":"e_1_2_13_11_1","first-page":"363","article-title":"Best Practices for the Use of Mechanical Thrombectomy in Acute Pulmonary Embolism: A Position Statement From the Society of Interventional Radiology","volume":"34","author":"Kuo W. T.","year":"2023","journal-title":"Journal of Vascular and Interventional Radiology"},{"key":"e_1_2_13_12_1","first-page":"e1","article-title":"Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension: A Scientific Statement From the American Heart Association","volume":"149","author":"Jaff M. R.","year":"2024","journal-title":"Circulation"},{"key":"e_1_2_13_13_1","first-page":"e1","article-title":"Catheter\u2010Based Therapies for Acute Pulmonary Embolism: A Review of Current Evidence and Future Directions","volume":"149","author":"Rosenfield K.","year":"2024","journal-title":"Circulation"},{"key":"e_1_2_13_14_1","first-page":"485","article-title":"Chinese Expert Consensus on Percutaneous Mechanical Thrombectomy for Acute Pulmonary Embolism","volume":"57","author":"Interventional Group, Radiology Society of Chinese Medical Association","year":"2023","journal-title":"Chinese Journal of Academic Radiology"},{"key":"e_1_2_13_15_1","first-page":"e237","article-title":"Management of Pulmonary Embolism: A Scientific Statement From the American Heart Association","volume":"149","author":"Giri J.","year":"2024","journal-title":"Circulation"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_2_13_18_1","first-page":"1378","article-title":"Definition of Clinically Relevant Bleeding in Patients With Venous Thromboembolism: A Scientific Statement From the International Society on Thrombosis and Haemostasis","volume":"20","author":"Piazza G.","year":"2022","journal-title":"Journal of Thrombosis and Haemostasis: JTH"},{"key":"e_1_2_13_19_1","first-page":"1153","article-title":"Training Standards in Percutaneous Coronary and Peripheral Vascular Interventions: A Consensus Statement From the Society for Cardiovascular Angiography and Interventions","volume":"99","author":"Klein A. 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A.","year":"2024","journal-title":"Haematologica"},{"key":"e_1_2_13_24_1","first-page":"1432","article-title":"The Post\u2010Thrombotic Syndrome and Its Impact on Quality of Life After Deep Vein Thrombosis","volume":"20","author":"Grosse A.","year":"2022","journal-title":"Journal of Thrombosis and Haemostasis: JTH"},{"key":"e_1_2_13_25_1","first-page":"485","article-title":"Validation of a Standardized Clinical Scale for the Diagnosis of Post\u2010Thrombotic Syndrome in Patients With a Previous Deep Vein Thrombosis","volume":"6","author":"Prandoni P.","year":"2008","journal-title":"Journal of Thrombosis and Haemostasis: JTH"},{"key":"e_1_2_13_26_1","article-title":"ERS Statement on Chronic Thromboembolic Pulmonary Hypertension","volume":"63","author":"Delcroix M.","year":"2024","journal-title":"European Respiratory Journal"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_13_29_1","first-page":"958","article-title":"Mid\u2010Term Outcomes After Mechanical Thrombectomy for Acute Intermediate\u2010Risk Pulmonary Embolism: The FLARE Study","volume":"16","author":"Sista A. K.","year":"2023","journal-title":"JACC: Cardiovascular Interventions"},{"key":"e_1_2_13_30_1","first-page":"1","article-title":"KKDIGO Clinical Practice Guideline for Acute Kidney Injury","volume":"2","author":"KDIGO Work Group","year":"2012","journal-title":"Kidney International Supplement"},{"key":"e_1_2_13_31_1","first-page":"589","article-title":"Right Ventricular Mechanics and Long\u2010Term Outcomes After Percutaneous Mechanical Thrombectomy for Acute Pulmonary Embolism: Insights From Serial Cardiac Magnetic Resonance","volume":"17","author":"Liang N.","year":"2024","journal-title":"JACC: Cardiovascular Imaging"},{"key":"e_1_2_13_32_1","first-page":"712","article-title":"Health\u2010Related Quality of Life Following Percutaneous Mechanical Thrombectomy for Intermediate\u2010Risk Pulmonary Embolism: Insights From the FLARE Study","volume":"17","author":"Sista A. K.","year":"2024","journal-title":"JACC: Cardiovascular Interventions"},{"key":"e_1_2_13_33_1","first-page":"712","article-title":"Quality of Life in Patients With Chronic Thromboembolic Pulmonary Hypertension and Changes After Pulmonary Endarterectomy","volume":"87","author":"Inami T.","year":"2023","journal-title":"Circulation Journal"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_13_35_1","first-page":"1189","article-title":"Percutaneous Mechanical Thrombectomy Versus Anticoagulation Alone for Intermediate\u2010Risk Pulmonary Embolism: A Multicenter Randomized Trial (PMT\u2010ANTICO)","volume":"149","author":"Piazza G.","year":"2024","journal-title":"Circulation"},{"key":"e_1_2_13_36_1","first-page":"369","article-title":"The Propensity Score: From Basic Theory to Modern Extensions","volume":"42","author":"Austin P. 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