{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:45:45Z","timestamp":1775709945051,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thrombosis\u2010induced stroke represents one of the most serious complications of atrial fibrillation (AF), and the presence of spontaneous echo contrast (SEC) is a well\u2010established echocardiographic predictor of pre\u2010thrombotic states. An 82\u2010year\u2010old woman with AF presented with recurrent ischemic strokes despite oral anticoagulation therapy and was referred to our center for left atrial appendage closure (LAAO). Transesophageal echocardiography (TEE) demonstrated slow flow within the left atrial appendage along with a large atrial septal aneurysm (ASA) exhibiting prominent SEC. Following multidisciplinary evaluation, simultaneous percutaneous closure of both the LAA and the ASA\/PFO was successfully performed. Postprocedural follow\u2010up demonstrated no device\u2010related thrombosis, peri\u2010device leak, or further stroke events. This case underscores the potential benefit of combined LAA and ASA\/PFO closure in high\u2010risk AF patients with recurrent embolic events despite anticoagulation.<\/jats:p>","DOI":"10.1002\/ccd.70415","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:37:37Z","timestamp":1765345057000},"page":"818-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter Closure for Prevention of Stroke in an Octogenarian Woman With Dual Left Atrial \u201cAppendages\u201d"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6572-518X","authenticated-orcid":false,"given":"Tao","family":"He","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine Chengdu China"},{"name":"Department of Cardiology and Center of Structure Heart Disease, Sichuan Provincial People's Hospital University of Electronic Science and 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