{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:06Z","timestamp":1791395406143,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sex\u2010related differences in the clinical presentation of coronary artery disease (CAD) are well recognized. The pullback pressure gradient (PPG) characterizes\u00a0pathophysiological CAD patterns as focal or diffuse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the influence of sex on residual angina at one year after percutaneous coronary intervention (PCI), stratified by PPG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a sub\u2010analysis of PPG Global, a multicenter, prospective, single\u2010arm study. All patients had hemodynamically significant CAD (fractional flow reserve [FFR] \u2264\u20090.80) and underwent a manual FFR pullbacks to calculate PPG before PCI. Patient\u2010reported outcomes were collected using the 7\u2010item Seattle Angina Questionnaire (SAQ\u20107) at baseline and 1\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 814 patients (205 [25.2%] women and 609 [74.8%] men). Women were significantly older than men (70\u2009\u00b1\u200910 years vs. 67\u2009\u00b1\u200910 years\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Baseline FFR were comparable between sexes (0.68\u2009\u00b1\u20090.13 vs. 0.66\u2009\u00b1\u20090.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.098), but women had a more focal CAD compared to men (PPG 0.66\u2009\u00b1\u20090.15 vs. 0.63\u2009\u00b1\u20090.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047). Post PCI\u2010FFR was higher in women than men (0.88\u2009\u00b1\u20090.07 vs. 0.87\u2009\u00b1\u20090.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041); however, angina at 1 year was more frequent in women (SAQ angina frequency score 94\u2009\u00b1\u200912 vs. 96\u2009\u00b1\u200910,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite having a more focal CAD pattern and achieving higher post\u2010PCI FFR, women report more residual angina than men at 1\u2010year follow\u2010up.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov NCT04789317.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70419","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T04:39:49Z","timestamp":1766032789000},"page":"987-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Sex on Residual Angina After Percutaneous Coronary Interventions"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-9188","authenticated-orcid":false,"given":"Masahiro","family":"Hada","sequence":"first","affiliation":[{"name":"Cardiovascular Center Aalst, AZORG Aalst Belgium"},{"name":"Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, AZORG Aalst Belgium"},{"name":"Division of Clinical Pharmacology, Department of Pharmacology Showa Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, AZORG Aalst Belgium"},{"name":"Department of Cardiology Tokyo Medical University Hachioji Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Munhoz","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, AZORG Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7081-4881","authenticated-orcid":false,"given":"Sofie","family":"Brouwers","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, AZORG Aalst Belgium"},{"name":"Department of Experimental Pharmacology, Faculty of Medicine and Pharmacy Vrije Universiteit Brussel Brussels 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