{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:12Z","timestamp":1791395412106,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronary angiography is the gold standard for assessing coronary artery disease (CAD), while the SYNTAX score (SxS) quantifies lesion complexity. Its prognostic value across clinical settings remains uncertain. This study compared angiographic findings in stable angina and acute coronary syndrome (ACS) using the SxS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective study was conducted at Shaikh Zayed Hospital, Lahore, over 12 months, including 156 patients undergoing coronary angiography: stable angina (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978) and ACS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978). Patients aged 18\u201380 years undergoing primary PCI or elective angiography were included, excluding prior PCI or CABG. Demographic and clinical data were collected, and SxS was applied post\u2010angiography. Data were analyzed using SPSS v.25, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05 considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 156 patients were enrolled (71.2% male; mean age 59.2\u2009\u00b1\u200910.6 years, BMI 27.2\u2009\u00b1\u20093.5\u2009kg\/m\u00b2), equally divided into stable angina (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978) and ACS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978). The overall mean SxS was 26.1\u2009\u00b1\u200911.3. Comparison between groups showed no significant differences in age, BMI, sex distribution, smoking, hypertension, or diabetes (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, dyslipidemia was more prevalent in ACS patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and the mean SxS was significantly higher in ACS versus stable angina (28.2\u2009\u00b1\u20099.9 vs. 23.8\u2009\u00b1\u200912.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), indicating greater angiographic complexity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The higher SxS in ACS patients indicated greater angiographic complexity, consistent with prior studies. Scores were also significantly elevated in patients with diabetes and hypertension, supporting the score's prognostic value in CAD stratification. However, the absence of clinical variables limits risk prediction. The single\u2010center design, small sample size, lack of adjusted analyses, and absence of long\u2010term outcomes further constrain generalizability, warranting validation in larger multicenter cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SxS was significantly higher in ACS than stable angina, supporting its role in guiding management, particularly in patients with comorbidities. Larger multicenter studies are needed to validate its prognostic utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70420","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T05:10:37Z","timestamp":1765861837000},"page":"949-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SYNTAX Score as a Predictor of Angiographic Complexity in Stable Angina and Acute Coronary Syndrome Patients"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-3557","authenticated-orcid":false,"given":"Sohaib","family":"Ashraf","sequence":"first","affiliation":[{"name":"Department of Cardiology Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"},{"name":"Rehmatul Lil Alameen post graduate Institute of cardiology PESSI Multan Road Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Mujtaba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutaba","family":"Akmal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sarmad","family":"Shahab","sequence":"additional","affiliation":[{"name":"Department of Pharmacology King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Shahbaz","sequence":"additional","affiliation":[{"name":"Pakistan kidney and liver institute and research center Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ahmad","family":"Imran","sequence":"additional","affiliation":[{"name":"Cancer Centre, Howard University Hospital Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meer Hassan","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Medicine Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-2583","authenticated-orcid":false,"given":"Sidra","family":"Ashraf","sequence":"additional","affiliation":[{"name":"University of Veterinary and Animal Sciences Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Kiwan","family":"Akram","sequence":"additional","affiliation":[{"name":"University of Veterinary and Animal Sciences Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama","family":"Bin Naeem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Riphah International University Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larab","family":"Kalsoom","sequence":"additional","affiliation":[{"name":"Department of Medicine Services Hospital Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonera","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sikandar","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anum","family":"Pari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Children's Hospital Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaryab","family":"Tahir","sequence":"additional","affiliation":[{"name":"Department of Medicine Gujrat Medical College Gujrat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbaz","family":"Tahir","sequence":"additional","affiliation":[{"name":"Department of Medicine Chughtai Lab Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qurrat ul Ain","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Medicine Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Punjab Institute of Cardiology Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Athar","family":"Mujtaba","sequence":"additional","affiliation":[{"name":"Department of Medicine Central Park Medical College Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifrah","family":"Batool","sequence":"additional","affiliation":[{"name":"Department of Medicine Independent University Hospital Faislabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj Ul","family":"Muneer","sequence":"additional","affiliation":[{"name":"Department of Medicine Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundas","family":"Rafique","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Mayo Hospital Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Howard University Hospital Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2439-8404","authenticated-orcid":false,"given":"Fatima","family":"Awais","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qazi Abdul","family":"Saboor","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shaikh Zayed Post\u2010Graduate Medical Complex Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moneeb","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Pharmacology King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Ross University School of Veterinary Medicine (RUSVM)  Saint Kitts and Nevis West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.17.1880-b"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.013631"},{"key":"e_1_2_11_5_1","article-title":"Acute Coronary Syndrome (Unstable Angina and Non\u2010ST Elevation MI)","volume":"2009","author":"Sarkees M. 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