{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:26:50Z","timestamp":1793957210581,"version":"4.8.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alternative access for transcatheter aortic valve implantation (TAVI) is required for the small subset of patients in whom transfemoral (TF) access is not feasible. The most commonly used alternative access route in the United Kingdom is the subclavian\/axillary artery, and historically, most have been performed via surgical cutdown. Transaxillary TAVI can be undertaken via a percutaneous route. However, there exists limited data on the safety and efficacy of this technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to describe the UK experience of percutaneous axillary (PAx) TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, multicenter study included every TAVI center in the United Kingdom which had performed &gt;\u200910 PAx TAVI cases as of November 1, 2023. Each center provided data on all PAx cases carried out up to December 31, 2023. Procedural and clinical endpoints as well as adverse events were assessed according to Valve Academic Research Consortium (VARC)\u20103 definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine UK TAVI centers contributed data from 210 PAx cases. VARC\u20103 technical success was achieved in 92.4%. The incidence of major VARC\u20103 vascular access site complications was 7.1%, major or life\u2010threatening VARC\u20103 bleeding occurred in 5.3%, a covered stent was used in 25.2%, and vascular surgical intervention was required in 3.3%. The incidence of in\u2010hospital stroke and mortality were 7.1% and 3.3%, respectively. No statistically significant differences were observed between PAx carried out under conscious sedation (non\u2010GA) and GA with respect to clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PAx TAVI is viable and can be performed under conscious sedation with no detriment in terms of clinical outcomes. However, the elevated risk of stroke is a concern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70435","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T04:59:24Z","timestamp":1766033964000},"page":"997-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcatheter Aortic Valve Implantation via Percutaneous Axillary Access\u2014A UK Registry"],"prefix":"10.1002","volume":"107","author":[{"given":"Noman","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Cunnington","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leeds Teaching Hospitals NHS Trust Leeds 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Cardiology Aberdeen Royal Infirmary Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul","family":"Baradi","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals NHS Trust Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hildick\u2010Smith","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre Brighton and Sussex University Hospitals NHS Trust Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hartley","sequence":"additional","affiliation":[{"name":"Department of Cardiology Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Cardiology Imperial College Healthcare NHS Trust London 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