{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:09Z","timestamp":1791395409770,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Arterial calcification is an important characteristic of vascular aging. Risk factors and clinical outcomes of percutaneous coronary intervention (PCI) procedure failure in patients with moderate\u2010to\u2010severe coronary artery calcification (MSCAC) have not been adequately assessed. We aimed to analyze the characteristics, risk factors, and long\u2010term clinical outcomes for patients with MSCAC with PCI procedure failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 26253 patients undergoing PCI at Fuwai Hospital between January 2017 and December 2018. Procedure failure was defined as residual stenosis\u2009\u2265\u200950%, severe angiographic complications, in\u2010hospital death, or in\u2010hospital myocardial infarction (MI). The primary endpoint was CV events, including CV death, nonfatal MI, and nonfatal stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median 3\u2010year follow\u2010up, 613 CV events were recorded. The incidence of PCI procedure failure for MSCAC patients was 10.96%. Compared with non\u2010MSCAC patients, the multivariable\u2010adjusted hazard ratio (aHR) for CV events was 2.38 (95% CI: 1.65\u20133.44) for MSCAC with PCI failure subjects, while no significant difference could be found between non\u2010MSCAC patients and MSCAC with PCI success patients. MSCAC patients with PCI procedure failure showed an increased risk of CV events (aHR: 2.16; 95% CI: 1.39\u20133.38) than those with procedure success. Application of intravascular ultrasound and rotational atherectomy were independent protective factors for the occurrence of MSCAC\u2010PCI procedure failure in patients with severe calcification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MSCAC patients with PCI procedure failure showed unfavorable long\u2010term clinical outcomes compared with those with PCI procedure success. IVUS and rotational atherectomy could reduce the risk of PCI procedure failure occurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70452","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:31:22Z","timestamp":1767004282000},"page":"1088-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Profile and Prognostic Implications of Percutaneous Coronary Intervention Procedure Failure in Patients With Moderate\u2010to\u2010Severe Coronary Artery Calcification"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-9724","authenticated-orcid":false,"given":"Zhangyu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Cardiometabolic 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