{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:20Z","timestamp":1791395420610,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on commissural misalignment (CMA) during valve\u2010in\u2010valve transcatheter aortic valve implantation (ViV\u2010TAVI) for valve failure after surgical aortic valve replacement (SAVR) is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To study the impact of CMA on clinical and hemodynamic outcomes following ViV\u2010TAVI for failed SAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of patients who underwent ViV\u2010TAVI for failed SAVR valves at two institutions (Heart Center Leipzig at Leipzig University, Leipzig, Germany; Cedars\u2010Sinai Smidt Heart Institute, Los Angeles, USA) were retrospectively collected and compared regarding the existence of CMA. Outcomes of interest included Valve Academic Research Consortium (VARC)\u20103\u2010based clinical endpoints, Computed Tomography\u2010based hypoattenuated leaflet thickening (HALT), hemodynamic outcome, and mid\u2010term all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 687 patients who underwent ViV\u2010TAVI, post\u2010procedural CT of sufficient quality to measure commissural alignment was available in 180 patients (47.8% females, mean age 78.0 years). Self\u2010expanding TAVI valves were used in 49.2% of the cases. CMA was found in 35 individuals (19.4%) and was associated with reduced VARC\u20103\u2010based technical success (80% vs. 93%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), driven by increased rates of coronary obstruction (17.1% vs. 5.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). The incidence of HALT was 31.7%, without differences in patients with and without CMA. VARC\u20103\u2010based device success was 62.9%, driven by an incidence of residual mean valve gradient (\u2265\u200920\u2009mmHg) of 35.4%, without differences between groups. Midterm survival after a mean of 747 days was 84.6% and comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For patients undergoing ViV\u2010TAVI for failed SAVR, technical success is reduced for cases of CMA due to higher odds of coronary obstruction, without differences in mid\u2010term survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70460","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:01:06Z","timestamp":1767855666000},"page":"1215-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Commissural Misalignment Following Valve\u2010in\u2010Valve Transcatheter Aortic Valve Implantation"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0087-7972","authenticated-orcid":false,"given":"Matthias","family":"Raschpichler","sequence":"first","affiliation":[{"name":"University Hospital of Cardiac Surgery Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-932X","authenticated-orcid":false,"given":"Johannes Rotta Detto","family":"Loria","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Patel","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Smidt Heart Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Noack","sequence":"additional","affiliation":[{"name":"University Hospital of Cardiac Surgery Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"N\u00fcsser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Dumpies","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhairya","family":"Patel","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Smidt Heart Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagasaka","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Smidt Heart Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Madaan","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Smidt Heart Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakriti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Smidt Heart Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-998X","authenticated-orcid":false,"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-1364","authenticated-orcid":false,"given":"Michael A.","family":"Borger","sequence":"additional","affiliation":[{"name":"University Hospital of Cardiac Surgery Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Smidt Heart Institute Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-558X","authenticated-orcid":false,"given":"Mohamed","family":"Abdel\u2010Wahab","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center Leipzig at Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.104505"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.483"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.1049"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024848"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx455"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.006730"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.06.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.05.043"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.04.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.02.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.595"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.02.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.12.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.038"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.05.034"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000854"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.09.039"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30757-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx369"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.01.045"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:53:37Z","timestamp":1791392017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccd.70460"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70460","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"2025-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}