{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:11Z","timestamp":1791395411448,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Percutaneous left atrial appendage occlusion (LAAO) has traditionally been performed under general anesthesia (GA) to maintain patient comfort and immobility, especially in the setting of transesophageal echocardiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to compare the safety and efficacy of conscious sedation (CS) compared to GA for LAAO, concurrent with the expansion of intracardiac echocardiography guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of the PubMed, Embase, Cochrane Central, and Scopus databases was conducted through December 2024 for studies comparing CS versus GA for LAAO. For outcomes of procedural complications and characteristics, random\u2010effects models were used to calculate the mean difference (MD), odds ratio (OR), and risk ratio (RR) effect estimates with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four studies with 1540 patients undergoing LAAO were included (CS\u2009=\u2009678, GA\u2009=\u2009862). CS was associated with significantly shorter total procedural time [MD \u221211.95\u2009min; 95% CI \u221219.52 to \u22122.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009] and a lower volume of contrast media [MD \u221231.90\u2009mL; 95% CI \u221256.72 to \u22127.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01]. No significant differences were noted for total fluoroscopy time, total length of hospital stay, device success, all\u2010cause mortality, cardiovascular mortality, stroke, device\u2010related thrombus, and peri\u2010device leak\u2009&gt;\u20095\u2009mm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Percutaneous LAAO using CS allows for faster procedures and lower contrast media volumes compared to GA without compromising device success and clinical outcomes. Randomized studies with longer follow\u2010ups are necessary to understand the long\u2010term outcomes of percutaneous LAAO using CS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70466","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:37:28Z","timestamp":1767854248000},"page":"1189-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conscious Sedation Versus General Anesthesia for Percutaneous Left Atrial Appendage Occlusion: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-4299","authenticated-orcid":false,"given":"Hritvik","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Internal Medicine All India Institute of Medical Sciences Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhant","family":"Passey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Connecticut Health Center Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Allegheny General Hospital Drexel University School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriti","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Pushparaji","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine MetroHealth Medical Center, Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-7314","authenticated-orcid":false,"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Heart and Lung Institute, Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravdeep S.","family":"Jhand","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Geisinger Medical Center Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Khera","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Goldsweig","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Baystate Medical Center and Division of Cardiovascular Medicine University of Massachusetts\u2010Baystate, Springfield Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00627"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.010310"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046451"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.31073"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16445"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2020.0184"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-040455"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0218492314548231"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.08.004"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2023.11.013"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.4022\/jafib.2200"},{"issue":"2","key":"e_1_2_13_17_1","first-page":"E124","article-title":"Safety, Efficacy, and Cost\u2010Effectiveness of Same\u2010Day Discharge for Left Atrial Appendage Occlusion","volume":"34","author":"Dallan L. A. P.","year":"2022","journal-title":"The Journal of Invasive Cardiology"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29376"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009669"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.040"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.10.030"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026656"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.07.009"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:53:18Z","timestamp":1791391998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccd.70466"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70466","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}