{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:15:50Z","timestamp":1775106950906,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The non\u2010coronary sinus pivot implantation (NCPI) technique has notably improved procedural success rate in transcatheter aortic valve replacement (TAVR) for cases of severe pure native aortic regurgitation (PNAR) when utilizing self\u2010expanding transcatheter heart valves (THVs). Nonetheless, the intrinsic anchoring mechanism remains obscure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to assess the feasibility of implementation of the NCPI method using self\u2010expanding THVs for TAVR in severe PNAR and dilated ascending aortas (AAOs), and to elucidate the anchoring mechanism of the NCPI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study consecutively enrolled patients with severe PNAR and significantly dilated AAOs, who underwent TAVR with a NCPI technique. Clinical outcomes and a composite of all\u2010cause mortality at 30 days and 12 months were assessed. Additionally, the post\u2010TAVR cardiac multidetector computed tomographies (MDCTs) were conducted to investigate the anchoring mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 12 patients were enrolled. The median age was 77 years, and the mean Society of Thoracic Surgery (STS) risk score was 10.1%, with a mean aortic annular perimeter of 80.0\u2009mm, a median ascending aortic diameter of 47.9\u2009mm. Device success rates were 100%. In all patients, post\u2010TAVR cardiac MDCT analysis revealed stable anchorage of the THV via the non\u2010coronary side insertion and the left\u2010coronary side compacting contact achieved by the NCPI method despite the presence of ascending aortic dilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preliminarily speaking, with the implementation of the NCPI method, the utilization of off\u2010label self\u2010expanding THVs for TAVR in severe PNAR and significantly dilated AAOs is deemed feasible. Stable anchorage of the THV was achieved using the NCPI method.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70469","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:42:44Z","timestamp":1768801364000},"page":"1361-1368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter Aortic Valve Replacement With Self\u2010Expanding Valves in Severe Pure Native Aortic Regurgitation\u2014Is It Still Anchored Stably in a Significantly Dilated Ascending Aorta Population?"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-8569","authenticated-orcid":false,"given":"Weijing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai Institute of Cardiovascular Diseases Shanghai China"},{"name":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital Fudan University Shanghai China"},{"name":"NHC Key Laboratory of Ischemic Heart Diseases Shanghai China"},{"name":"Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Provincial Clinical Medical College, Fujian Medical University, Fuzhou University Affiliated Provincial Hospital Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wuhan Asian Heart Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangpeng","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai Institute of Cardiovascular Diseases Shanghai China"},{"name":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital Fudan University Shanghai China"},{"name":"NHC Key Laboratory of Ischemic Heart Diseases Shanghai China"},{"name":"Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences Shanghai China"},{"name":"National Clinical Research Center for Interventional Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Zhongshan Hospital Fudan University Shanghai 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