{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:17:23Z","timestamp":1775107043541,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Physical decline after transcatheter aortic valve implantation (TAVI) is associated with worse outcomes. However, data on post\u2010TAVI extremity function are limited. This sub\u2010study of the TAVI XS trial aimed to assess extremity function after transfemoral TAVI, evaluate functional decline, compare outcomes between upper\u2010and lower\u2010extremity secondary access approaches and identify predictors of functional decline after TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The TAVI XS was a randomized clinical trial comparing upper\u2010 and lower\u2010extremity secondary access during TAVI. Patients were assessed for extremity function at baseline and at 30 days using the Lower Extremity Function Scale (higher score indicating better function) and the Quick Disabilities of the Arm, Shoulder, and Hand questionnaire (higher score indicating worse function).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lower\u2010extremity (45.0 [IQR 35.0\u201357.0] to 52.0 [39.0\u201363.0];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and upper\u2010extremity function (11.4 [2.3\u201325.0] to 6.8 [0\u201322.7];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) improved after TAVI. Relevant decline in lower\u2010extremity function occurred in 20 (8.4%) patients, and in upper\u2010extremity function in 19 (8.0%) patients. No differences in post\u2010TAVI function were observed between upper\u2010 or lower\u2010extremity secondary access (lower\u2010extremity: 10.1% vs. 6.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35, upper\u2010extremity: 7.6% vs. 8.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.81). Predictors (OR [95% CI]) of clinically relevant decline were baseline use of dual antiplatelet therapy\/oral anticoagulants (4.17 [1.39\u201312.49];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) for lower\u2010extremity function and multiple punctures (4.05 [1.46\u201311.24];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) for upper\u2010extremity function. Age inversely affected lower\u2010 (0.92 [0.85\u20130.99\/year];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and upper\u2010extremity function (0.93 [0.86\u20130.99\/year];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of clinically relevant decline in extremity function after TAVI is low. No differences in reported extremity function were observed between the upper\u2010 and lower\u2010extremity secondary access approach. Predictors of decline were antithrombotic therapy and multiple punctures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05672823.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70470","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:44:53Z","timestamp":1768297493000},"page":"1293-1302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extremity Function After Transfemoral Transcatheter Aortic Valve Implantation: A TAVI XS Sub\u2010Study"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1583-2953","authenticated-orcid":false,"given":"Geert A. A.","family":"Versteeg","sequence":"first","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim J. P.","family":"Rooijakkers","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley I.","family":"Hemelrijk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter J.","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1368-5499","authenticated-orcid":false,"given":"Dani\u00ebl C.","family":"Overduin","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen H.","family":"van Wely","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo M.","family":"Aarts","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk\u2010Jan","family":"van Ginkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7487-151X","authenticated-orcid":false,"given":"Niels A.","family":"Stens","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands"},{"name":"Department of Medical Biosciences Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokien X.","family":"van Nunen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-5932","authenticated-orcid":false,"given":"Robert Jan","family":"van Geuns","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leen A. F. M.","family":"van Garsse","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume S. C.","family":"Geuzebroek","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel W. A.","family":"Verkroost","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysun","family":"Cetinyurek\u2010Yavuz","sequence":"additional","affiliation":[{"name":"Department of IQ Health, Section Biostatistics Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin H.","family":"Heijmen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-5567","authenticated-orcid":false,"given":"Dick H. 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