{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:17:26Z","timestamp":1775107046186,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Quantitative flow ratio (QFR) is effective in predicting mortality in patients undergoing transcatheter aortic valve replacement (TAVR). How QFR reclassifies coronary artery disease (CAD) at vessel\u2010level compared to angiography and how this influences the risk of death, remains undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We calculated QFR from consecutive 280 TAVR patients with bystander coronary stenoses. All lesions were managed conservatively. Angiographic CAD was defined by a diameter stenosis\u2009\u2265\u200950%, functional CAD by a QFR\u2009\u2264\u20090.80. The outcome was mortality at 3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 635 lesions were included. Angiographic CAD was evident in 165 (26.0%), functional CAD in 17 (11.2%) (reclassification:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Angiography\/QFR mismatch occurred in 22.5%, mostly in large vessels and lesions located in the proximal left anterior descending (LAD). QFR\u2009\u2264\u20090.80 was an independent predictor of death (HR 2.91, 95% CI 1.94\u22124.36;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The risk was progressively increased for lower QFR values and positive QFR at LAD site (vs. QFR\u2009&gt;\u20090.80 HR: 3.92, 95% CI 2.78\u22125.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; vs. QFR\u2009\u2264\u20090.80 at non\u2010LAD site: HR 2.65, 95% CI 1.07\u22126.59;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>QFR leads to a significant reclassification of CAD rates at vessel\u2010level and shows a significant prognostic value in patients undergoing TAVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70491","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:30:51Z","timestamp":1769743851000},"page":"1407-1417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vessel\u2010Oriented Analysis on the Relationship Between Quantitative\u2010Flow Ratio and Mortality in Patients With Severe Aortic Stenosis and Intermediate Coronary Lesions"],"prefix":"10.1002","volume":"107","author":[{"given":"Iginio","family":"Colaiori","sequence":"first","affiliation":[{"name":"Division of Cardiology Santa Maria Goretti Hospital Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3290-4053","authenticated-orcid":false,"given":"Luca","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Clinico San Carlos Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Mangiacapra","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Campus Bio\u2010Medico Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-0117","authenticated-orcid":false,"given":"Giulia","family":"Nardi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Clinico San Carlos Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Clinico San Carlos Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5150-188X","authenticated-orcid":false,"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[{"name":"Cardiology Unit Azienda Ospedaliera Universitaria di Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Biscaglia","sequence":"additional","affiliation":[{"name":"Cardiology Unit Azienda Ospedaliera Universitaria di Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Versaci","sequence":"additional","affiliation":[{"name":"Division of Cardiology Santa Maria Goretti Hospital Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Biondi\u2010Zoccai","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Biotechnologies Sapienza University of Rome Latina Italy"},{"name":"Maria Cecilia Hospital, GVM Care &amp; Research Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille","family":"Gaspardone","sequence":"additional","affiliation":[{"name":"Division of Cardiology Sant' Eugenio Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Vitolo","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia, Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0409","authenticated-orcid":false,"given":"Giorgio","family":"Benatti","sequence":"additional","affiliation":[{"name":"Cardiology Department Azienda Ospedaliero\u2010Universitaria of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Vignali","sequence":"additional","affiliation":[{"name":"Cardiology Department Azienda Ospedaliero\u2010Universitaria of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia, Policlinico di Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Guiducci","sequence":"additional","affiliation":[{"name":"Cardiology Unit Azienda USL\u2010IRCCS Reggio Emilia, S. 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