{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:17:50Z","timestamp":1775107070993,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trans\u2010catheter aortic valve replacement (TAVR) in patients with large annuli poses procedural difficulties and possible complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We sought to compare the peri\u2010procedural and long\u2010term outcomes of patients with large annuli undergoing TAVR with self\u2010expanding (SEV) versus balloon\u2010expandable (BEV) valves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted propensity score matching (PSM) of consecutive male patients with large aortic annuli (aortic valve area\u2009\u2265\u2009540\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ) enrolled in a national registry undergoing TAVR with SEVs and BEVs between 2008 and 2023. The cutoff for the large annulus was based on definitions set by the S3 manufacturer. Patients undergoing TAVR via the transapical route, for aortic regurgitation, and prior valve interventions were excluded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 552 patients were included in the current analysis (368 BEV; 184 SEV; age 80.2\u2009\u00b1\u20098.2\u2009y\/o). Baseline characteristics were similar between groups. The rate of peri\u2010procedural cardiopulmonary resuscitation (CPR) (3.9% vs. 0.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), hemodynamic instability (5.8% vs. 1.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), major or life\u2010threatening bleeding (7.7% vs. 2.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and need for a second valve (3.8% vs. 0.3%) was higher in the SEV versus BEV group. In univariate analysis the 3\u2010year mortality rate was higher in the SEV versus BEV group (29.4% vs. 20.4%; log rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). However, multivariate analysis adjusted for known confounders related to mortality did not show a significant difference between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Male patients with large aortic annuli undergoing TAVR with either SEV or BEV have similar rates of in\u2010hospital and long\u2010term mortality, albeit a notably higher rate of peri\u2010procedural complications related to SEVs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70494","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:49:17Z","timestamp":1770616157000},"page":"1506-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TAVR in Male Patients With Large Aortic Valve Annuli: A Propensity\u2010Matched Analysis of Balloon\u2010Expandable Versus Self\u2010Expanding Valves"],"prefix":"10.1002","volume":"107","author":[{"given":"Lior","family":"Zornitzki","sequence":"first","affiliation":[{"name":"Department of Cardiology Tel Aviv Sourasky Medical Center Tel Aviv\u2010Yafo Israel"},{"name":"School of Medicine, Grey Faculty of Health Sciences Tel Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itamar","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel Aviv Sourasky Medical Center Tel Aviv\u2010Yafo Israel"},{"name":"School of Medicine, Grey Faculty of Health Sciences Tel Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shir","family":"Frydman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel Aviv Sourasky Medical Center Tel Aviv\u2010Yafo Israel"},{"name":"School of Medicine, Grey Faculty of Health Sciences Tel Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maayan","family":"Konigstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel Aviv Sourasky Medical Center Tel Aviv\u2010Yafo Israel"},{"name":"School of Medicine, Grey Faculty of Health Sciences Tel Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Ben\u2010Shoshan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel Aviv Sourasky Medical Center Tel Aviv\u2010Yafo Israel"},{"name":"School of Medicine, Grey Faculty of Health Sciences Tel Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Arbel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel Aviv Sourasky Medical Center Tel Aviv\u2010Yafo Israel"},{"name":"School of Medicine, Grey Faculty of Health Sciences Tel Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Barbash","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Leviev Heart and Vascular Center, Chaim Sheba Medical Center, Ramat Gan, Israel affiliated with School of Medicine Tel Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-8253","authenticated-orcid":false,"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Cardiology Department Rabin Medical Center Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabby G.","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hadassah Medical Center Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem Jerusalem 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