{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:15:44Z","timestamp":1775106944404,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018536","name":"National Mega Project on Major Infectious Disease Prevention","doi-asserted-by":"publisher","award":["2024ZD0527500"],"award-info":[{"award-number":["2024ZD0527500"]}],"id":[{"id":"10.13039\/501100018536","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The safety and efficacy of aspirin combined with ticagrelor or clopidogrel remain unclear in ST\u2010segment elevation myocardial infarction (STEMI) patients with Diabetes mellitus (DM) and poor glycemic control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to assess the efficacy and safety of ticagrelor versus clopidogrel\u2013based dual antiplatelet therapy in STEMI patients with DM and poor glycemic control undergoing pPCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated 2732 STEMI patients with DM and poor glycemic control who underwent primary percutaneous coronary intervention (pPCI) and were registered in the \u201cImproving Care for Cardiovascular Disease in China\u2010Acute Coronary Syndrome (CCC\u2010ACS)\u201d program between November 2014 and December 2019. Using propensity score matching (PSM) and cox proportional hazards regression, we compared the in\u2010hospital risk of major adverse cardiovascular events (MACCE), TIMI bleeding events, and net adverse clinical events (NACE) between patients receiving aspirin combined with either ticagrelor or clopidogrel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, the risk of in\u2010hospital MACCE (HR\u2009=\u20090.545, 95% CI: 0.321\u20130.926,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025), Cardiac death (HR\u2009=\u20090.380, 95% CI: 0.149\u20130.971,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) and NACE (HR\u2009=\u20090.728, 95% CI: 0.560\u20130.947,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) was significantly lower in the ticagrelor group compared with the clopidogrel group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while no significant difference was observed in the incidence of TIMI\u2010bleeding events between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among STEMI patients with DM and poor glycemic control undergoing pPCI, ticagrelor use was associated with a low rate of MACCE, without an excessive risk of bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The information of clinical trial registration for CCC\u2010ACS project can be found at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/study\/NCT02306616\">http:\/\/clinicaltrials.gov\/study\/NCT02306616<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70503","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:44:38Z","timestamp":1770623078000},"page":"1562-1572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aspirin Combined With Ticagrelor or Clopidogrel in STEMI Patients With Diabetes Mellitus and Poor Glycemic Control Undergoing Primary PCI: A Multicenter Retrospective Cohort Study"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8822-6599","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute General Hospital of Northern Theater Command Shenyang Liaoning China"},{"name":"School of Clinical Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute General Hospital of Northern Theater Command Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute General Hospital of Northern Theater Command Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoxi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute General Hospital of Northern Theater Command Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meicen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute General Hospital of Northern Theater Command Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1979-0287","authenticated-orcid":false,"given":"Xiaozeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute General Hospital of Northern Theater Command Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"issue":"13","key":"e_1_2_10_2_1","first-page":"771","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"151","author":"Rao S. 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