{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:28Z","timestamp":1778825308128,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve implantation (TAVI) has become an established intervention for severe symptomatic aortic stenosis, particularly in high\u2010risk and elderly patients. Although anemia is frequently encountered in this population, the specific role of iron deficiency anemia (IDA) in influencing outcomes following TAVI remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to evaluate the impact of iron deficiency anemia on clinical outcomes, resource utilization and readmission rates following TAVI using a large national database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, observational study using the Nationwide Readmission Database (NRD) from 2016 to 2021. Patients undergoing TAVI were identified by relevant ICD\u201010\u2010Procedure Coding System (PCS) codes, and IDA was defined using ICD\u201010\u2010Clinical Modification (CM) codes. Outcomes included in\u2010hospital mortality, 30\u2010day readmission, length of stay (LOS), transfusion requirements, and a range of complications. A 1:1 propensity score\u2010matched analysis was performed to account for potential confounders (e.g., demographics, comorbidities, hospital characteristics).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 213,453 patients who underwent TAVI, 8993 (4.2%) had a documented diagnosis of IDA. Compared with non\u2010IDA patients, those with IDA experienced significantly higher rates of blood transfusion (14.75% vs. 5.33%; adjusted OR: 3.12, 95% CI: 2.78, 3.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a greater incidence of post\u2010procedure bleeding (14.38% vs. 11.62%; adjusted OR: 1.29, 95% CI: 1.17, 1.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Although in\u2010hospital mortality did not differ significantly between the two groups (1.31% vs. 1.47%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.42), IDA was associated with a longer median LOS and higher 30\u2010day readmission rates (11.95% vs. 9.84%; adjusted OR: 1.27, 95% CI: 1.15, 1.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Advancing age, the presence of heart failure, and greater comorbidity burden (Elixhauser comorbidity index \u2265\u20097) emerged as key predictors of in\u2010hospital death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline IDA in patients undergoing TAVI is associated with increased transfusion requirements, prolonged hospitalization, and higher rates of 30\u2010day readmission, underscoring the clinical and economic burden of this modifiable risk factor. Its association with greater resource utilization and complications supports the need for more proactive identification and management of iron deficiency in TAVI candidates. Future randomized trials are needed to clarify whether preprocedural correction of IDA can reduce adverse events and improve long\u2010term outcomes in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70504","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T09:52:48Z","timestamp":1771149168000},"page":"1641-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Iron Deficiency Anemia on Outcomes After Transcatheter Aortic Valve Implantation: Insights From the Nationwide Readmission Database From 2016 to 2021"],"prefix":"10.1002","volume":"107","author":[{"given":"Siddharth P.","family":"Agrawal","sequence":"first","affiliation":[{"name":"New York Medical College\/Landmark Medical Center Woonsocket Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubhadarshini","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cedars Sinai Medical Center Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-3762","authenticated-orcid":false,"given":"Debankur","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical College Kolkata Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1239-6465","authenticated-orcid":false,"given":"Dhruvi K.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Narendra Modi Medical College and Sheth L.G. Hospital Ahmedabad Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maharshi","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Medical Center, Brighton Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-4299","authenticated-orcid":false,"given":"Hritvik","family":"Jain","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Jodhpur Rajasthan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid","family":"Siddiq","sequence":"additional","affiliation":[{"name":"Department of Cardiology NYMC\/Landmark Medical Center Woonsocket Rhode Island 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