{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:15:26Z","timestamp":1775106926581,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aortic stenosis leads to left ventricular remodeling, hypertrophy, and fibrosis, increasing the risk of heart failure. Renin\u2212angiotensin system (RAS) inhibitors may mitigate these adverse effects and improve clinical outcomes. Despite advancements in transcatheter aortic valve replacement (TAVR), substantial mortality, heart failure readmissions, and other complications persist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the impact of RAS inhibitor therapy following TAVR on clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and Bayesian meta\u2010analysis following the Cochrane Handbook for Systematic Reviews of Interventions. A comprehensive search of PubMed, Embase, and Cochrane was performed to identify studies comparing RAS inhibitor (RASi) use versus non\u2010use in patients undergoing TAVR for aortic stenosis. Odds ratios (OR) and 95% credible intervals (CrI) were estimated using a Bayesian random\u2010effects model. Between\u2010study heterogeneity was quantified using the posterior distribution of the heterogeneity parameter (\u03c4). Posterior probabilities (PP) of treatment benefit were calculated, with clinically meaningful effects defined as P (OR\u2009&lt;\u20090.8). All analyses were performed using R version 4.5.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 12 studies comprising 35,988 patients were included, of whom 17,026 (47.3%) received RASi therapy. The mean age ranged from 78.9 to 84.4 years. Post\u2010TAVR RASi use was associated with a 79.4% probability of a clinically relevant reduction in all\u2010cause mortality and a 99.5% probability of a clinically relevant reduction in cardiovascular mortality. There was a 54% probability of a clinically relevant reduction in heart failure hospitalization and a negligible (2.26%) probability of a reduction in the odds of myocardial infarction in the RASi group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RASi therapy following TAVR is associated with reduced odds of mortality and heart failure readmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70506","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:32:31Z","timestamp":1770622351000},"page":"1554-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Bayesian Meta\u2010Analysis of Renin\u2212Angiotensin System Inhibitors Following TAVR"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-6870","authenticated-orcid":false,"given":"Vin\u00edcius Martins Rodrigues","family":"Oliveira","sequence":"first","affiliation":[{"name":"Federal University of Goi\u00e1s Goi\u00e2nia Brazil"},{"name":"Instituto de Cardiologia e Radiologia Intervencionista de Rio Verde Rio Verde Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-2115","authenticated-orcid":false,"given":"Lucas M.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais Belo Horizonte Brazil"},{"name":"Instituto do Coracao\u2010InCor\u2010Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Ant\u00f4nio de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Federal University of Uberl\u00e2ndia Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Duarte","family":"Lima","sequence":"additional","affiliation":[{"name":"University of Rio Verde Rio Verde Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonia Cruz","family":"Akabane","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Borges","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8734-3802","authenticated-orcid":false,"given":"Edmundo Damiani","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Hospital e Maternidade Marieta Konder Bornhausen Itaja\u00ed Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00edsio","family":"Bulh\u00f5es","sequence":"additional","affiliation":[{"name":"Universidade da Amaz\u00f4nia Reunida Reden\u00e7\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alexandre","family":"Farias","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4023-5970","authenticated-orcid":false,"given":"Roberto","family":"Mazetto","sequence":"additional","affiliation":[{"name":"State University of Amazon Manaus Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Roberto Ferreira","family":"Tartuce Filho","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia e Radiologia Intervencionista de Rio Verde Rio Verde Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Willian Anast\u00e1cio","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Aurus Oliveira Brazil"},{"name":"Interventional Cardiology Unit Hospital S\u00e3o Judas Tadeu Oliveira Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Bignoto","sequence":"additional","affiliation":[{"name":"Instituto do Coracao\u2010InCor\u2010Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunna","family":"Pileggi","sequence":"additional","affiliation":[{"name":"Instituto do Coracao\u2010InCor\u2010Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto Graner","family":"Moreira","sequence":"additional","affiliation":[{"name":"Federal University of Goi\u00e1s Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludimilla Pereira","family":"Tartuce","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia e Radiologia Intervencionista de Rio Verde Rio Verde Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1505"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.035460"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000001897"},{"key":"e_1_2_8_5_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022)","author":"Higgins J. P. T.","year":"2022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2024.11.002"},{"key":"e_1_2_8_10_1","article-title":"Are We Missing the Forest for the Trees? How Bayesian Meta\u2010Analysis Could Reshape Evidence in Cardiology","volume":"107","author":"Oliveira V. M. R.","year":"2025","journal-title":"Catheterization and Cardiovascular Interventions"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2004"},{"key":"e_1_2_8_12_1","article-title":"A Bayesian Meta\u2010Analysis of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Small Aortic Annulus","author":"Oliveira V. M. R.","year":"2025","journal-title":"Cardiovascular Revascularization Medicine"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1234368"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz769"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2022.12.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvac027"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18077"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.11.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.15171\/jcvtr.2019.30"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.08.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311738"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.05.055"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2024.101212"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.02.011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.05.006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz275"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.192997"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.07.022"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28899"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102016"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2500366"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2023-322922"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:46:12Z","timestamp":1775101572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ccd.70506"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70506","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]},"assertion":[{"value":"2025-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}