{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:45:12Z","timestamp":1789584312954,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nodular calcification (NC) lesions in the femoropopliteal artery (FPA) are associated with poor outcomes after drug\u2010coated balloon (DCB) angioplasty due to inadequate expansion and limited drug uptake. Jetstream atherectomy may enhance vessel preparation and improve DCB efficacy; however, the clinical outcome for FPA NC lesions remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy of DCB following Jetstream versus DCB alone for FPA NC lesions in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective, multicenter study, we enrolled 2213 consecutive patients (2294 de novo FPA lesions) who underwent EVT between 2018 and 2023. Of these, 94 FPA NC lesions with DCB following Jetstream and 197 FPA NC lesions with DCB alone were analyzed. Propensity score matching was performed to compare clinical outcomes between the two strategies, and 76 pairs were analyzed. The primary outcome was primary patency at 1 year, and target lesion revascularization (TLR) was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 1 year, DCB following Jetstream achieved significantly higher primary patency and freedom from TLR compared with DCB alone (DCB following Jetstream vs. DCB alone: 87.5% vs. 70.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017; 95.7% vs. 84.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047, respectively). Limb salvage and overall survival did not differ significantly between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DCB following Jetstream showed better clinical outcomes compared to DCB alone for FPA NC lesions in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70510","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:30:25Z","timestamp":1770708625000},"page":"1584-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Clinical Outcome of Drug\u2010Coated Balloon Following Jetstream and Drug\u2010Coated Balloon for Femoropopliteal Nodular Calcification Lesions: The Results of the Multicenter ORION Study"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8563-6854","authenticated-orcid":false,"given":"Kenji","family":"Ogata","sequence":"first","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Nishihira","sequence":"additional","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-062X","authenticated-orcid":false,"given":"Takahiro","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya Heart Center Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-3794","authenticated-orcid":false,"given":"Naoki","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1436","authenticated-orcid":false,"given":"Akiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sendai Kosei Hospital Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-2165","authenticated-orcid":false,"given":"Shunsuke","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yokohama Eastern Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-1277","authenticated-orcid":false,"given":"Takashi","family":"Yanagiuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rakuwakai Otowa Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-473X","authenticated-orcid":false,"given":"Tatsuro","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tenyoukai Central Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-6438","authenticated-orcid":false,"given":"Tatsuya","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Medical Center Chiba Japan"},{"name":"Department of Surgery, Division of Vascular Surgery The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshisato","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4314-259X","authenticated-orcid":false,"given":"Kenichi","family":"Tsujita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The LEADers PAD 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