{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:17:32Z","timestamp":1780546652092,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgorund<\/jats:title>\n                    <jats:p>Drug\u2010coated balloon (DCB) angioplasty offers a potential alternative to avoid permanent metallic stent implantation and the associated risk of in\u2010stent restenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the safety and effectiveness of DCB angioplasty for de novo coronary stenoses in real\u2010world clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010center, retrospective observational study. Between March 2017 and October 2023, patients who underwent DCB angioplasty for at least one de novo coronary stenosis were included. The primary endpoint was the device\u2010oriented composite endpoint (DOCE), defined as a composite of cardiovascular death, device failure\u2010related myocardial infarction, or device failure\u2010related target lesion revascularization. Post\u2010procedural angiography\u2010derived fractional flow reserve (vFFR) was evaluated after DCB angioplasty in eligible patients with angiograms of adequate quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 255 de novo coronary stenoses undergoing DCB angioplasty were analyzed. Among the treated lesions, 92.5% were located in the main epicardial vessels. Cutting or scoring balloons and rotational atherectomy were employed for lesion preparation in 14.5% and 5.9% of lesions, respectively. The bailout stenting rate was 1.9%. During a follow\u2010up duration of 558\u2009\u00b1\u2009499 days, the primary endpoint, DOCE, occurred in 13 lesions (5.1%). Post\u2010procedural vFFR was analyzable in 130 lesions. Residual stenosis \u2264\u200930% was achieved in only 39.1% of lesions, whereas 80.7% of lesions demonstrated a post\u2010procedural vFFR \u2265\u20090.75.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing DCB angioplasty for de novo coronary stenoses demonstrated favorable clinical outcomes during mid\u2010term follow\u2010up. The clinical utility of vFFR in the context of DCB angioplasty warrants further investigation in large\u2010scale studies to determine its impact on clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70527","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:44:55Z","timestamp":1772977495000},"page":"1701-1708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physiologic Assessment Using Angiography\u2010Derived Fractional Flow Reserve After Drug\u2010Coated Balloon Angioplasty in De Novo Coronary Lesions"],"prefix":"10.1002","volume":"107","author":[{"given":"Chun\u2010Chin","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin Lin","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ting","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Medicine, Division of Cardiology Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Lin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010I.","family":"Teng","sequence":"additional","affiliation":[{"name":"Heart Center Cheng Hsin General Hospital Taipei 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