{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:20:48Z","timestamp":1790619648368,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Managing patients with high\u2010bleeding risk (HBR) requiring percutaneous coronary intervention (PCI) is challenging, and data are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study investigates the clinical outcomes of drug\u2010coated balloon (DCB)\u2010based PCI compared to drug\u2010eluting stent (DES)\u2010only PCI in patients with HBR undergoing PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 652 consecutive patients with HBR undergoing DCB\u2010based PCI and compared them to 652 propensity\u2010matched patients who received conventional PCI with second\u2010generation DES. Patients were followed up for 2 years to assess major adverse cardiovascular events (MACE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline clinical characteristics were comparable between the groups. In the DCB\u2010based PCI group, 71.6% of patients were successfully treated with DCB alone. In the DCB\u2010based PCI, patients had lower cardiac mortality at 2 years (2.0% vs. 5.2%; hazard ratio: 0.37; 95% confidence interval: 0.18\u20130.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Rates of target vessel revascularization (2.5% vs. 6.0%; hazard ratio: 0.43; 95% confidence interval: 0.24\u20130.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), and major bleeding events (1.4% vs. 5.4%; hazard ratio: 0.26; 95% confidence interval: 0.12\u20130.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) were also lower with DCB\u2010based PCI than with DES\u2010only PCI. Myocardial infarction events were comparable between the two groups. In a multivariable model, DCB\u2010based PCI was independently associated with reduced risk of 2\u2010year cardiac death, target vessel revascularization, and major bleeding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with HBR, DCB\u2010based PCI was associated with a significantly lower risk of MACE compared to DES\u2010only treatment. These findings suggest that DCB\u2010based PCI may be a viable treatment strategy for improving outcomes in patients with HBR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70528","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:52:02Z","timestamp":1772977922000},"page":"1709-1717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drug\u2010Coated Balloon\u2010Based Versus Drug\u2010Eluting Stent\u2010Only Treatment for Patients With High\u2010Bleeding Risk"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-6968","authenticated-orcid":false,"given":"Eun\u2010Seok","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Cardiology Ulsan University Hospital, University of Ulsan College of Medicine Ulsan Republic of 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Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-6843","authenticated-orcid":false,"given":"Ae\u2010Young","family":"Her","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Kangwon National University School of Medicine Chuncheon Republic of 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