{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:29Z","timestamp":1778825309591,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lipid\u2010rich plaques are strongly associated with adverse cardiac events. However, the vascular response of lipid\u2010rich lesions to drug\u2010coated balloon (DCB) angioplasty has not been fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to compare vascular responses following DCB angioplasty between lipid\u2010rich and non\u2010lipid\u2010rich lesions in patients with chronic coronary syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included patients scheduled for paclitaxel\u2010coated balloon angioplasty for de novo small\u2010vessel lesions in the setting of chronic coronary syndrome between February 2021 and April 2024. All patients underwent pre\u2010 and post\u2010procedural near\u2010infrared spectroscopy combined with intravascular ultrasound (NIRS\u2010IVUS), along with follow\u2010up coronary angiography and NIRS\u2010IVUS at 8 months. Lesions were categorized as lipid\u2010rich or non\u2010lipid\u2010rich based on the pre\u2010procedural maximum lipid core burden index over 4\u2009mm (maxLCBI\n                      <jats:sub>4\u2009<\/jats:sub>\n                      mm). Changes in plaque volume and maxLCBI\n                      <jats:sub>4<\/jats:sub>\n                      mm from post\u2010procedure to the 8\u2010month follow\u2010up, as well as the incidence of late lumen enlargement (LLE), were compared between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six patients were included in the final analysis: 15 in the lipid\u2010rich group and 31 in the non\u2010lipid\u2010rich group. LLE occurred in 27% of the lipid\u2010rich group and 39% of the non\u2010lipid\u2010rich group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.52). Percent plaque volume showed minimal change in the lipid\u2010rich group (+0.3%), while a significant reduction was observed in the non\u2010lipid\u2010rich group (\u22123.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045). Conversely, maxLCBI\n                      <jats:sub>4<\/jats:sub>\n                      mm significantly decreased in the lipid\u2010rich group compared with the non\u2010lipid\u2010rich group (\u2212240 vs. \u221242;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0030), resulting in comparable values at the 8\u2010month follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Paclitaxel\u2010coated balloon treatment was associated with favorable outcomes, including LLE and a reduction in maxLCBI\n                      <jats:sub>4<\/jats:sub>\n                      mm, irrespective of lipid burden. However, the mechanisms underlying LLE may differ between lipid\u2010rich and non\u2010lipid\u2010rich lesions, suggesting potential heterogeneity in biological responses to DCB therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70534","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:29:14Z","timestamp":1772980154000},"page":"1732-1742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in Vascular Responses and Underlying Mechanisms Following Paclitaxel\u2010Coated Balloon Angioplasty Between Lipid\u2010Rich and Non\u2010Lipid\u2010Rich Lesions in Chronic Coronary Syndrome"],"prefix":"10.1002","volume":"107","author":[{"given":"Yutaka","family":"Matsuhiro","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka 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