{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:28Z","timestamp":1778825308101,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) has become the standard treatment for most patients with severe aortic stenosis. However, data on long\u2010term mortality and durability of transcatheter heart valves (THVs) is limited. The Hydra CE study previously reported good early\u2010 and medium\u2010term clinical performance and safety for TAVR with Hydra self\u2010expanding THV (Vascular Innovations Co Ltd, Nonthaburi, Thailand, a subsidiary of Sahajanand Medical Technologies Limited, India).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We herein report 5\u2010year follow\u2010up results from the long\u2010term follow\u2010up cohort of the Hydra CE study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Hydra CE was a prospective, multicenter, single\u2010arm study that enrolled 157 patients. Of these, 54 patients from two participating centers (Lithuania and Poland) provided consent for extended follow\u2010up (up to 5 years), forming the long\u2010term follow\u2010up cohort. These patients were monitored for up to 5 years to assess the durability and sustained performance of the device. The primary endpoint of this cohort was all\u2010cause mortality, with patients monitored for both clinical and echocardiographic outcomes throughout the follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 54 patients, the mean age was 81.0\u2009\u00b1\u20094.1 years. At 5\u2010year follow\u2010up, all\u2010cause mortality was 24.3%, with cardiovascular deaths accounting for 6.0% of the patients. Effective orifice area increased from 0.68\u202f\u2009\u00b1\u2009\u202f0.15\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      to 2.09\u202f\u2009\u00b1\u2009\u202f0.57\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and mean aortic valve gradient decreased from 53.4\u202f\u2009\u00b1\u2009\u202f14.24\u2009mmHg to 8.0\u2009\u00b1\u2009\u202f3.14\u2009mmHg at 5 years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Improvement of at least one NYHA functional class from baseline to 5 years was observed in 65% of patients. New permanent pacemaker implantation rate at 5\u2010year follow\u2010up was 16.7%. There were no cases of valve endocarditis, thrombosis, or structural valve deterioration over 5 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 5\u2010year results from the long\u2010term follow\u2010up cohort of the Hydra CE study established excellent valve durability and sustained hemodynamic performance. The study demonstrated favorable long\u2010term safety and clinical performance of the Hydra THV, with acceptable survival rates at 5\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70536","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:00:54Z","timestamp":1772989254000},"page":"1782-1790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Five\u2010Year Clinical and Hemodynamic Evaluation of the Hydra Self\u2010Expanding Transcatheter Heart Valve in Patients With Severe Aortic Stenosis"],"prefix":"10.1002","volume":"107","author":[{"given":"Vilhelmas","family":"Bajoras","sequence":"first","affiliation":[{"name":"Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine Vilnius University Vilnius Lithuania"},{"name":"Division of Cardiology and Vascular Diseases Vilnius University Hospital Santaros 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