{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:28Z","timestamp":1778825308158,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The JETSTREAM atherectomy device, particularly in its blades\u2010up mode, enables extensive debulking of calcified femoropopliteal (FP) lesions but may increase the risk of distal embolization, and its effect on patency after drug\u2010coated balloon (DCB) angioplasty remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The present study aimed to evaluate the efficacy and safety of the blades\u2010up function in JETSTREAM\u2010assisted DCB treatment for calcified FP lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between October 2021 and December 2024, 240 patients underwent JETSTREAM atherectomy for calcified FP lesions at eight centers in Japan. Of these, 232 who underwent DCB angioplasty alone were analyzed. Patients were stratified according to blades\u2010up use (with or without;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009116 each). Propensity score matching was performed to minimize baseline differences. The primary endpoint was 1\u2010year freedom from restenosis. Secondary endpoints included 1\u2010year freedom from clinically driven target lesion revascularization (CD\u2010TLR), acute limb ischemia (ALI), and major amputation. Procedure\u2010related endpoints were the minimum lumen area (MLA) at the debulked segment after DCB and the incidence of persistently impaired flow on final angiography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Propensity score matching yielded 56 well\u2010balanced pairs with no significant baseline differences. One\u2010year freedom from restenosis was similar between the non\u2010blades\u2010up and blades\u2010up groups. CD\u2010TLR, ALI, and major amputation rates were also comparable. Among patients with available intravascular imaging data (non\u2010blades\u2010up group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945; blades\u2010up group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942), post\u2010DCB MLA did not differ significantly. Persistent impaired flow on final angiography was infrequent and comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Blades\u2010up atherectomy did not provide additional benefits in vessel patency, clinical outcomes, or procedural results after DCB angioplasty. Routine blade\u2010up use may not be necessary when treating calcified FP lesions.\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      This study was not a prospective clinical trial; therefore, it was not registered.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70537","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:17:08Z","timestamp":1773008228000},"page":"1808-1818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Year Outcomes of Drug\u2010Coated Balloon Angioplasty With and Without the Blades\u2010Up Function of the JETSTREAM Atherectomy Device in Femoropopliteal Calcified Lesions"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-473X","authenticated-orcid":false,"given":"Tatsuro","family":"Takei","sequence":"first","affiliation":[{"name":"Department of Cardiology Tenyoukai Central Hospital Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-062X","authenticated-orcid":false,"given":"Takahiro","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya Heart Center Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-3794","authenticated-orcid":false,"given":"Naoki","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ogaki Municipal Hospital Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1436","authenticated-orcid":false,"given":"Akiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sendai Kousei Hospital Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-2165","authenticated-orcid":false,"given":"Shunsuke","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Urayasu Ichikawa Medical Center Urayasu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama City Eastern Hospital Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yanagiuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rakuwakai Otowa Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-6438","authenticated-orcid":false,"given":"Tatsuya","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Bay Urayasu Ichikawa Medical Center Urayasu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The LEADers PAD 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