{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:26Z","timestamp":1778825306850,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) has evolved significantly, expanding its indication to lower surgical risk patients. However, challenges remain, including conduction disorders or paravalvular leak (PVL). The ALLEGRA TAVI system (Biosensors International) is a supra\u2010annular self\u2010expanding prosthesis designed to optimize implantation and hemodynamic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of this study was to analyze short\u2010term outcomes following the implantation of the Allegra valve in real\u2010world practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study included 500 patients who underwent TAVR with the Allegra valve across 11 Spanish centers between 2017 and 2024. Success rates, complications, and 30\u2010day clinical outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age was 82.1\u2009\u00b1\u20095.5 years. The overall success rate was 96.8% (95% CI 94.8%\u221298.0%), with complications in 11.6% (95% CI 8.0%\u221213.0%) of cases. The need for permanent pacemaker implantation (PPI) was 19.2% (95% CI 16.0%\u221222.9%), while moderate\u2010to\u2010severe PVL occurred in 4.1% (95% CI 2.7%\u22126.3%). The in\u2010hospital mortality rate was 1.0% (95% CI 0.5%\u22122.6%). Hemodynamic performance was favorable, with post\u2010implant mean gradients of 4.0\u2009mmHg (IQR 2.0\u22125.0\u2009mmHg) in native aortic stenosis and 7.0\u2009mmHg (IQR 5.0\u221210.0\u2009mmHg) in valve\u2010in\u2010valve procedures. A reduction in complications was observed, but not significantly, with increased experience (15.2% vs. 10.4%,\n                      <jats:italic>p<\/jats:italic>\n                      0.147), though without impact on success rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirms that the Allegra valve is a safe and effective TAVR option, with outcomes comparable to other self\u2010expanding prostheses. Further design optimization could reduce PVL and PPI rates. Long\u2010term studies are needed to assess durability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70538","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:29:33Z","timestamp":1772987373000},"page":"1826-1834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Experience With a Suprannular Self\u2010Expanding Transcatheter Aortic Valve: The ALLOW Study"],"prefix":"10.1002","volume":"107","author":[{"given":"Ignacio","family":"Cruz\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Salamanca CIBERCV (Centro de Investigaciones Cardiovasculares en Red), IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dia de Salamanca) Salamanca 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D\u00edaz","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario Alvaro Cunqueiro Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canton","family":"Rubio","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda Hospital Universitario de Toledo Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Trillo","sequence":"additional","affiliation":[{"name":"Cardiology Department Complejo Hospital Universitario de Santiago, CIBERCV (Centro de Investigaciones Cardiovasculares en Red) Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-3502","authenticated-orcid":false,"given":"Rafael","family":"Romaguera","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda Hospital de Bellvitge Barcelona Spain"},{"name":"Bio\u2010Heart Cardiovascular Diseases Research Group Bellvitge 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