{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:28Z","timestamp":1778825308631,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a 54\u2010year\u2010old woman with stable angina who exhibited heterogeneous responses of tandem left anterior descending artery (LAD) plaques to intensive lipid\u2010lowering therapy. Coronary CT angiography performed at another hospital suggested diffuse disease, and she presented to our clinic for a second opinion. Intravascular ultrasound revealed a lipid\u2010rich proximal LAD lesion and a fibrous\u2010predominant distal lesion, along with a smaller intermediate lesion. Fractional flow reserve (FFR) pullback showed distal LAD FFR of 0.50, increasing to 0.73 across the distal lesion (\u0394FFR\u2009+\u20090.23) and to 0.95 across the proximal lesion (\u0394FFR\u2009+\u20090.22). Although PCI was considered, in accordance with the patient's preference and guideline recommendations, medical therapy with high\u2010intensity statin, ezetimibe, aspirin, nebivolol, and isosorbide dinitrate was initiated. LDL\u2010C decreased to &lt;\u200935\u2009mg\/dL and remained consistently suppressed. After 2 years, serial CT and intravascular ultrasound (IVUS) demonstrated near\u2010complete regression of the lipid\u2010rich proximal lesion with lumen enlargement, a marked reduction in IVUS features consistent with a lipid\u2010rich core, and attenuation of its lesion\u2010specific physiological contribution (\u0394FFR\u2009+\u20090.02), whereas the distal fibrous lesion remained stable (\u0394FFR\u2009+\u20090.20) (lesion\u2010specific functional improvement defined as attenuation of lesion\u2010specific \u0394FFR contribution on FFR pullback). The intermediate lesion also regressed morphologically, although it was not assessed functionally. The patient remained asymptomatic with preserved exercise capacity. This case suggests that plaque morphology may influence the response to lipid\u2010lowering therapy and highlights the value of multimodality imaging with lesion\u2010specific physiological assessment in individualized management of stable coronary disease.<\/jats:p>","DOI":"10.1002\/ccd.70543","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:10:36Z","timestamp":1773375036000},"page":"1917-1921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plaque Morphology\u2010Dependent Regression of Tandem Coronary Plaques Under Intensive Lipid\u2010Lowering Therapy"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0316-5689","authenticated-orcid":false,"given":"Yong\u2010Lee","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoun\u2010Woo","family":"Noh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Ok","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Rang","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KyeHwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Ree","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Yong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Gyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangyul","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Sin","family":"Koh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.jpc60002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110874"},{"issue":"6","key":"e_1_2_7_6_1","first-page":"627","article-title":"Plaque Microstructures in Patients With Coronary Artery Disease Treated With Intensive Statin Therapy: Serial OCT Analysis","volume":"9","author":"Kataoka Y.","year":"2016","journal-title":"JACC Cardiovasc 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