{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:32Z","timestamp":1778825312616,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute limb ischemia (ALI) is a critical vascular emergency associated with high risks of mortality and amputation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the 1\u2010year outcomes of Endovascular revascularization (EVR) in patients with ALI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 304 EVR procedures in 280 patients with ALI between January 2018 and April 2025 in three cardiovascular centers. The primary endpoint was 1\u2010year amputation\u2010free survival (AFS). Secondary endpoints were 1\u2010year clinically driven target lesion revascularization (CD\u2010TLR) and procedural success. The association of baseline characteristics with 1\u2010year AFS was also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The estimated 1\u2010year AFS rate was 65.2%, and freedom from CD\u2010TLR was 83.9%. Procedural success was achieved in 285 (93.8%) cases. Independent predictors of reduced 1\u2010year AFS included frailty (multivariable hazard ratio [mHR] 2.73; 95% confidence interval (CI), 1.62\u20134.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hemodialysis (mHR 2.76; 95% CI, 1.55\u20134.90;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), severe ALI (mHR 1.70; 95% CI, 1.03\u20132.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037), and peak creatine phosphokinase (CPK)\u2009&gt;\u20097000 IU\/L (mHR 2.95; 95% CI, 1.80\u20134.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In contrast, preserved flow in one below\u2010the\u2010knee (BTK) artery (mHR 0.44; 95% CI, 0.22\u20130.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) or in two or more BTK arteries (mHR 0.34; 95% CI, 0.17\u20130.69;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) was independently associated with improved 1\u2010year AFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EVR may be an acceptable treatment for ALI. Frailty, hemodialysis, severe ALI, and peak CPK\u2009&gt;\u20097000 IU\/L are associated with poor prognosis. However, achieving adequate BTK arterial flow after EVR may correlate with improved patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70555","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:58:55Z","timestamp":1773374335000},"page":"1908-1916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Year Clinical Outcomes of Endovascular Revascularization in Patients With Acute Limb Ischemia: Results of the Multicenter SKYLINE3 Study"],"prefix":"10.1002","volume":"107","author":[{"given":"Hiromi","family":"Miwa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Asahi General Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Asahi General Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Tobita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8563-6854","authenticated-orcid":false,"given":"Kenji","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital Miyazaki 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