{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:33Z","timestamp":1778825313785,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Mitral stenosis (MS) is still a significant cause of cardiovascular morbidity and mortality in low\u2010 and middle\u2010income countries, despite being nearly eradicated in the developed world. Percutaneous balloon mitral valvuloplasty (PBMV) is the treatment of choice for appropriate patients with MS, but traditional predictors such as mitral valve area and regurgitation grade fail to fully reflect long\u2010term prognosis. This review aims to analyze pre\u2010 and post\u2010PBMV hemodynamic changes in the left atrium and determine their prognostic significance in predicting clinical outcomes in patients with MS. This meta\u2010analysis followed PRISMA guidelines and was registered in PROSPERO (CRD420251017356). PubMed, Scopus, and Web of Science were searched on March 23, 2025, for studies on adults \u2265\u200918 years with isolated MS undergoing PBMV. Eligible studies reported both pre\u2010 and post\u2010procedure valve and hemodynamic parameters. Primary outcomes included mitral valve area, mean gradient, and left atrial indices. Pooled analyses were conducted in R (v 4.5.1). This meta\u2010analysis included the outcomes of PBMV by comparing pre\u2010 and post\u2010procedural data from 30 studies consisting of 2239 participants. Post\u2010PBMV outcomes revealed a significant increase in mitral valve area (MD 0.8834, 95% CI: 0.80; 0.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), cardiac output (MD 0.70, 95% CI: 0.58; 0.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and alongside significant reductions in left atrial diameter (MD \u22124.47; 95% CI: \u22126.23 to \u22122.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), left atrial pressure (MD \u22129.51, 95% CI: \u221211.19; \u22127.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), mitral valve pressure (MD \u22128.58, 95% CI: \u22129.41; \u22127.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and systolic pulmonary pressure (MD \u221217.96, 95% CI: \u221221.48; \u221214.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Out of 2239 patients, 71, 37, and 32 had valve replacement, PBMV repetition, and experienced death, respectively. PBMV showed promising effectiveness and safety in treating patients with MS with a significant increase in cardiac output and MV area and a significant decrease in LA diameter, LA pressure, MV pressure, and systolic pulmonary pressure post\u2010PBMV, while observing low adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70558","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:15:03Z","timestamp":1774606503000},"page":"2078-2097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Atrium and Mitral Valve Hemodynamics in Patients With Mitral Stenosis Pre and Post\u2010Percutaneous Balloon Mitral Valvuloplasty: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3742-5684","authenticated-orcid":false,"given":"Mohammad A.","family":"Zaied","sequence":"first","affiliation":[{"name":"Faculty of Medicine Jordan University of Science and Technology Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7486-0608","authenticated-orcid":false,"given":"Muhammad","family":"Shahzaib","sequence":"additional","affiliation":[{"name":"King Edward Medical University Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2330-183X","authenticated-orcid":false,"given":"Muhammad","family":"Mukhlis","sequence":"additional","affiliation":[{"name":"Ayub Medical College Abbottabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2841-0928","authenticated-orcid":false,"given":"Javeria","family":"Latif","sequence":"additional","affiliation":[{"name":"Allama Iqbal Medical College Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0987-0272","authenticated-orcid":false,"given":"Noor","family":"Fatima","sequence":"additional","affiliation":[{"name":"Gomal Medical College Dera Ismail Khan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2568-1697","authenticated-orcid":false,"given":"Fareeda","family":"Brohi","sequence":"additional","affiliation":[{"name":"Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0456-022X","authenticated-orcid":false,"given":"Umama","family":"Alam","sequence":"additional","affiliation":[{"name":"Khyber Medical College Peshawar Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8921-2248","authenticated-orcid":false,"given":"Pranjal","family":"Singh","sequence":"additional","affiliation":[{"name":"Kirori Mal College Delhi University Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14495"},{"key":"e_1_2_12_3_1","unstructured":"S. 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