{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:25Z","timestamp":1778825305379,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Advanced heart failure (HF) remains a clinical challenge, and mitral transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) has emerged as a potential bridging strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe the clinical outcomes of M\u2010TEER in a single\u2010center cohort of patients with advanced HF and to identify anatomical and clinical features potentially associated with increased procedural complexity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case series included 13 consecutive patients with advanced HF and moderate\u2010to\u2010severe or severe mitral regurgitation (MR) who underwent M\u2010TEER using the MitraClip system. Clinical, echocardiographic, and hemodynamic data were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age was 58 years (range 39\u201364), and the median EuroSCORE II was 10.4% (3.86\u201315.07). All patients had reduced left ventricular (LV) ejection fraction (median 22%) and enlarged LV dimensions (end\u2010systolic diameter &gt;\u200970\u2009mm in 38%). The mean tenting height was 15.4\u2009\u00b1\u20092.5\u2009mm. Five patients (38.4%) required continuous inotropic support. Procedural success was achieved in all cases, with no periprocedural or 30\u2010day mortality. Over a median follow\u2010up of 287 days (171\u2013483), four patients (30.7%) died, one (7.6%) underwent urgent heart transplantation, and two (15.3%) had elective transplantation. Four of five patients on inotropes (80%) were weaned off support. At 1 year, 61.5% of patients remained free from the composite endpoint of death, HF hospitalization, urgent transplant, or LV assist device implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>M\u2010TEER was feasible and safe in selected patients with advanced HF. This cohort presented anatomical and clinical features that may have contributed to greater procedural complexity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70574","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:20:08Z","timestamp":1774268408000},"page":"2013-2021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitral Transcatheter Edge\u2010to\u2010Edge Repair in Patients With Advanced Heart Failure: A Single\u2010Center Experience and Insights Into Anatomical and Clinical Determinants of Procedural Complexity"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2402-2565","authenticated-orcid":false,"given":"Pedro Castilhos de Freitas","family":"Crivelaro","sequence":"first","affiliation":[{"name":"Interventional Cardiology Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Rio Grande do Sul 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Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Vugman","family":"Wainstein","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Clausell","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Heart Transplant Program Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia Adams","family":"Goldraich","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Heart Transplant Program Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe 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