{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:08:24Z","timestamp":1778825304633,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Development of conduction abnormalities requiring pacing after transcatheter aortic valve replacement (TAVR) is relatively common. The effects of post\u2010TAVR permanent pacemaker (PPM) implantation on mortality, ischemic stroke, and cardiovascular outcomes remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the incidence, predictors, and cardiovascular outcomes of post\u2010TAVR permanent pacemaker implantation, including its association with 1\u2010year ischemic stroke risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adults undergoing TAVR (2008\u20132019;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091101) were evaluated. Patients with prior PPM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104) and\/or valve\u2010in\u2010valve or redo TAVR (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) were excluded. PPM placement was identified post\u2010indexed TAVR admission based on procedure codes, including both in\u2010hospital and post\u2010discharge implantations. Primary outcomes included 1\u2010year mortality, major adverse cardiovascular events (MACE), myocardial infarction (MI), and ischemic stroke. Multivariate logistic regression was performed to identify independent predictors of 1\u2010year ischemic stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within the TAVR cohort (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091101), 158 patients (14.4%) received PPM within 1\u2010year, including 135 (12.3%) in\u2010hospital and 23 post\u2010discharge. PPM was not associated with a significant difference in 1\u2010year mortality (15.8% vs. 14.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.816) or 1\u2010year MACE (20.9% vs. 21.0%, p\u2009=\u20091.000). However, PPM was associated with significantly lower ischemic stroke rate at 1 year (1.3% vs. 4.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044). In multivariate analysis adjusting for age, sex, and comorbidities, PPM was associated with 77% lower risk of 1\u2010year ischemic stroke (adjusted OR 0.234, 95% CI 0.056\u20130.977,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046). Late PPM implantation (&gt;\u20093 days) was associated with numerically higher 1\u2010year mortality (30.0% vs. 14.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.647) and MACE (36.7% vs. 17.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.119) compared to early implantation, though these outcomes did not reach statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PPM after TAVR was not associated with increased mortality or MACE but was independently associated with significantly lower ischemic stroke risk. Late PPM implantation showed a trend toward worse outcomes. These findings suggest that appropriately indicated PPM may confer cerebrovascular protection, and early implantation when indicated may be preferable. These findings warrant further validation in prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70579","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:40:27Z","timestamp":1775040027000},"page":"2124-2134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement: Incidence, Predictors, and Association With Reduced Ischemic Stroke Risk"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8132-9370","authenticated-orcid":false,"given":"Omar","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Macon and Joan Brock Virginia Health Sciences at Old Dominion University Eastern Virginia Medical School Norfolk Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8820-2050","authenticated-orcid":false,"given":"Nicholas J.","family":"Valle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Macon and Joan Brock Virginia Health Sciences at Old Dominion University Eastern Virginia Medical School Norfolk Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinjer","family":"Li","sequence":"additional","affiliation":[{"name":"Eastern Virginia Medical School Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Arizona Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israa","family":"Saleh","sequence":"additional","affiliation":[{"name":"Eastern Virginia Medical School Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Benza","sequence":"additional","affiliation":[{"name":"Eastern Virginia Medical School Macon and Joan Brock Virginia Health Sciences at Old Dominion University Norfolk Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak R.","family":"Talreja","sequence":"additional","affiliation":[{"name":"Department of Structural Cardiology Sentara Medical Group, Sentara Health Virginia Beach Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Structural Cardiology Sentara Medical Group, Sentara Health Virginia Beach Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2025.03.028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz924"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.03.034"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30788"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.07.043"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.020"},{"key":"e_1_2_7_9_1","unstructured":"A.Johnson L.Bulgarelli T.Pollard et al. \u201cMIMIC\u2010IV (Version 3.1) RRID:SCR_007345 \u201d PhysioNet 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