{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:11:01Z","timestamp":1780312261762,"version":"3.54.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal denervation (RDN) according to the latest ESH guidelines can be considered as a treatment option for patients with resistant hypertension. However, excess sympathetic nervous system activity constitutes an underlying pathophysiological mechanism in many disorders other than arterial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis investigated the therapeutic effects of RDN beyond arterial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were conducted following PRISMA guidelines. Electronic databases (PubMed, Embase, Cochrane) were searched for studies assessing RDN effects in atrial fibrillation (AF) recurrence, obstructive sleep apnea (OSA), metabolic parameters, heart failure (HF) and diastolic heart function. Inclusion criteria encompassed randomized controlled trials and observational studies with relevant outcome measures. Effect sizes were pooled using a random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 16 studies comprising 818 patients were included. RDN was associated with a significant increase in freedom from AF when combined with pulmonary vein isolation (RR: 1.30, 95% CI: 1.04 to 1.61,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20095%), an improvement in OSA severity as measured by the apnea\u2010hypopnea index (MD: \u22124.80, 95% CI: \u221212.60 to 3.01,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200939%), and decreased fasting blood glucose (MD: \u221210.04, 95% CI: \u221226.51 to 6.43,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Additionally, RDN led to improvements in left ventricular diastolic function in terms of E\/e' reduction (MD: \u22121.51, 95% CI: \u22122.71 to \u22120.31,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200994%) and improved HF\u2010related biomarkers, specifically NT pro\u2010BNP (MD: \u2212438.54, 95% CI: \u22121658.57 to 781.49,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200992%) and 6\u2010min walking distance (MD: +64.58, 95% CI: 0.11 to 129.05,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200953%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis suggests that RDN exerts beneficial effects beyond hypertension, particularly in AF burden, OSA severity, metabolic parameters, and cardiac function. These findings support the broader role of RDN in autonomic regulation and cardiovascular health. Further large\u2010scale trials are warranted to confirm these effects and refine patient selection criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70600","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:54:37Z","timestamp":1775123677000},"page":"2153-2161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Favorable Effects of Renal Denervation in Hypertension\u2010Related Comorbidities. A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0313-7473","authenticated-orcid":false,"given":"Athanasios","family":"Makris","sequence":"first","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios","family":"Soulaidopoulos","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-1368","authenticated-orcid":false,"given":"Marios","family":"Sagris","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-2704","authenticated-orcid":false,"given":"Konstantinos","family":"Platanias","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kyriakoulis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Tatakis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Gompos","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-8905","authenticated-orcid":false,"given":"Kyriakos","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-4601","authenticated-orcid":false,"given":"Athanasios","family":"Kordalis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsiachris","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Kafkas","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital KAT Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Waliszewski","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health (BIH) at Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"1st Cardiology Department Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00647.2009"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa237"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573402115666190301154100"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.034"},{"key":"e_1_2_12_7_1","article-title":"Renal Sympathetic Denervation in Patients With Heart Failure With Preserved Ejection Fraction","volume":"14","author":"Kresoja K. 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