{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:11:01Z","timestamp":1780312261845,"version":"3.54.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with heart failure with reduced ejection fraction (HFrEF) were excluded from major trials of left atrial appendage occlusion (LAAO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The objective of this study was to describe this population and evaluate outcomes after LAAO in patients with and without HFrEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with and without HFrEF undergoing LAAO were identified in the Nationwide Readmissions Database from 2016 to 2020. Outcomes of interest were major in\u2010hospital adverse events (death, stroke, pericardial effusion, tamponade, pericardial window, transfusion) and 6\u2010month readmissions (any readmission, heart failure readmission, death\/stroke readmission). To account for differences between patients with and without HFrEF, outcomes were evaluated using risk\u2010adjusted logistic regression models and risk\u2010adjusted Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 50,526 encounters for LAAO, 5895 (11.7%) patients had HFrEF. The HFrEF group had a lower proportion of women and a higher proportion of major cardiovascular comorbidities. CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASC score was 3.8\u2009\u00b1\u20091.3 in the HFrEF group and 3.7\u2009\u00b1\u20091.4 in those without HFrEF. HFrEF was associated with a higher risk of composite in\u2010hospital major adverse events (6.0% vs. 5.0%, adjusted OR 1.23 [95% CI 1.09\u22121.40],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and a higher risk of 6\u2010month all\u2010cause readmission (adjusted HR 1.18 [95% CI 1.08\u22121.28],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), heart failure readmission (adjusted HR 1.59 [95% CI 1.46\u22121.72],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and readmission with death or stroke (adjusted HR 1.27 [95% CI 1.03\u22121.57],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One out of nine patients treated with LAAO in the United States has HFrEF, which is associated with a higher risk of major in\u2010hospital complications and hospital readmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70607","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:51:03Z","timestamp":1775623863000},"page":"2345-2352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Left Atrial Appendage Occlusion in Heart Failure With Reduced Ejection Fraction"],"prefix":"10.1002","volume":"107","author":[{"given":"Aamer","family":"Ubaid","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Allegheny General Hospital Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam","family":"Bagga","sequence":"additional","affiliation":[{"name":"Krieger School of Arts &amp; Sciences Johns Hopkins University Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine St Lukes Mid America Heart Institute Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Saxon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan P.","family":"Huded","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine St Lukes Mid America Heart Institute Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022274"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.19102\/icrm.2018.090402"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15192"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057063"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.11909\/j.issn.1671-5411.2021.05.003"},{"issue":"4","key":"e_1_2_12_8_1","first-page":"293","article-title":"Relationship of Left Atrial Appendage Function to Left Ventricular Function","volume":"56","author":"Mahilmaran A.","year":"2004","journal-title":"Indian Heart Journal"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac043"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009026"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00961"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.07.003"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000361040"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035090"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.02.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.09.007"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005997"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.05.006"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-01010"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00903-X"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.5.547"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-01006-x"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70607","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:52:56Z","timestamp":1780311176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccd.70607"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70607","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}