{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:32:43Z","timestamp":1786559563869,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is a frequent comorbidity in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI). In addition, new\u2010onset AF can occur after TAVI. However, data on how AF affects outcomes in patients undergoing TAVI remain conflicting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess clinical outcomes in patients with severe aortic valve stenosis with AF who undergo TAVI in a large real\u2010world global cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CENTER2\u2010study includes 25,771 patients that underwent TAVI between 2007 and 2022. The database consists of patient\u2010level pooled data from 10 clinical studies. Objectives were rates of new\u2010onset AF\u2009\u2264\u200930 days, and differences in mortality and stroke according to AF status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 23,320 patients were included in the current analysis (56.1% female; mean age 81.5\u2009\u00b1\u20096.7 years). Pre\u2010existing AF was present in 28.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096579) of patients. Mortality rates after TAVI were higher in patients with pre\u2010existing AF (19.0% vs. 14.2%, adjusted HR: 1.39, 95% CI: 1.26\u20131.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Strokes at Day 3\u201330 after TAVI were more frequent in patients with pre\u2010existing AF (1.6% vs. 1.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). New\u2010onset AF occurred in 6.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009681) of patients without pre\u2010existing AF. Mortality rates after TAVI were higher in patients with new\u2010onset AF (adjusted HR 1.75, 95% CI 1.24\u20132.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). One\u2010year stroke was more frequently observed in patients with new\u2010onset AF after exclusion of acute periprocedural stroke (6.1% vs. 3.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Major bleeding was also more frequent in patients with new\u2010onset AF (12.0% vs. 6.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with pre\u2010existing or new\u2010onset AF had higher mortality compared with patients without AF undergoing transfemoral TAVI. After the acute postprocedural period, 1\u2010year stroke rates were higher in patients with new\u2010onset AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      . Unique identifier NCT03588247.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70632","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:45:57Z","timestamp":1776797157000},"page":"114-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010Existing and New\u2010Onset Atrial Fibrillation in Patients Undergoing Transcatheter Aortic Valve Implantation"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-189X","authenticated-orcid":false,"given":"Kimberley I.","family":"Hemelrijk","sequence":"first","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam Cardiovascular Sciences Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-2296","authenticated-orcid":false,"given":"Astrid C.","family":"van Nieuwkerk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam Cardiovascular Sciences Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philomene J.","family":"Vojacek","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam Cardiovascular Sciences Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-6095","authenticated-orcid":false,"given":"Livia","family":"Gheorge","sequence":"additional","affiliation":[{"name":"Hospital Puerto del mar Cadiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Tch\u00e9tch\u00e9","sequence":"additional","affiliation":[{"name":"Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Fabio S. de","family":"Brito","sequence":"additional","affiliation":[{"name":"Heart Institute University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-5437","authenticated-orcid":false,"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Enna \u201cKore\u201d Enna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-8253","authenticated-orcid":false,"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Cardiology Department Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-343X","authenticated-orcid":false,"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"Department of Cardiology Montefiore Medical Center New York New York USA"},{"name":"Department of Medicine Division of Cardiology University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"D'Onofrio","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-0304","authenticated-orcid":false,"given":"Flavio","family":"Ribichini","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey Yanes","family":"Bowden","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario de Canarias Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dumonteil","sequence":"additional","affiliation":[{"name":"Clinique Pasteur Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-8528","authenticated-orcid":false,"given":"Rogerio Sarmento","family":"Leite","sequence":"additional","affiliation":[{"name":"Heart Institute University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-9409","authenticated-orcid":false,"given":"Samantha","family":"Sartori","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"D'Errigo","sequence":"additional","affiliation":[{"name":"National Centre for Global Health\u2010Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6115-5822","authenticated-orcid":false,"given":"Stefano","family":"Andreaggi","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Orvin","sequence":"additional","affiliation":[{"name":"Cardiology Department Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-7871","authenticated-orcid":false,"given":"Matteo","family":"Pagnesi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties, Radiological Sciences and Public Health Institute of Cardiology, ASST Spedali Civili University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-5834","authenticated-orcid":false,"given":"Lluis","family":"Asmarats","sequence":"additional","affiliation":[{"name":"Hospital de Sant Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-9423","authenticated-orcid":false,"given":"Ronak","family":"Delewi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC Amsterdam Cardiovascular Sciences Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.06.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.09.036"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.061"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010304"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.05.104"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.01.018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100910"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.07.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007546"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.10.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I7A121"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa799"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.08.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.06.010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.037"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.110981"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000132470.78896.A8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032901","article-title":"Cerebrovascular Events in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation: A Pooled Patient\u2010Level Study","volume":"13","author":"Nieuwkerk A. 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