{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:32:41Z","timestamp":1786559561748,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The coexistence of severe mitral regurgitation (MR) and mild\u2010to\u2010moderate aortic stenosis (AS) presents diagnostic and therapeutic challenges. Limited data exists on outcomes following mitral transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) therapy in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study is aimed to evaluate clinical outcomes following M\u2010TEER in patients with mild\u2010to\u2010modearte AS compared with those without aortic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010center retrospective study was conducted on 238 patients who underwent M\u2010TEER therapy between January 2014 and December 2024. Patients with severe AS, cardiogenic shock, and failed or aborted cases were excluded. We compared patients with mild\u2010to\u2010moderate AS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) to those without AS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009208). Primary outcome: Acute hypoxemic respiratory failure (AHRF) within 24\u2009h (SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009\u2264\u200990%\u2009\u2265\u200930\u2009min or need for O\n                      <jats:sub>2<\/jats:sub>\n                      \/NIV\/IMV, adjudicated as cardiogenic). Secondary outcomes: Post\u2010procedural in\u2010hospital mortality, acute kidney injury, hospital length of stay (LOS), 30\u2010day rate of heart failure hospitalization (HFH), and 30\u2010day rate of all\u2010cause readmission. Multivariable logistic regression was used to identify independent predictors of AHRF, hospital LOS, and 30\u2010day HFH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following M\u2010TEER, the mild\u2010to\u2010moderate AS group experienced significantly higher rates of AHRF (16.7% vs. 3.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0142; adjusted OR 4.38, 95% CI 1.36\u201314.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). Within the parsimonious adjusted model, AS remained independently associated with AHRF, whereas the other included covariates were not. There was no significant difference in the 30\u2010day rate of all\u2010cause readmission, 30\u2010day rate of HFH, AKI, LOS, or in\u2010hospital mortality between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients undergoing M\u2010TEER, the presence of mild\u2010to\u2010moderate AS is independently associated with an increased risk of early post\u2010procedural AHRF, without differences in other short\u2010term clinical outcomes. Given the single\u2010center retrospective design and the limited number of clinical events, these findings should be considered hypothesis\u2010generating and warrant validation in larger, prospective, multicenter studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70639","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:30:43Z","timestamp":1777001443000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Hypoxemic Respiratory Failure Following Mitral Transcatheter Edge\u2010to\u2010Edge Repair: The Role of Aortic Stenosis"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4802-6795","authenticated-orcid":false,"given":"Mark","family":"Sonbol","sequence":"first","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-4388","authenticated-orcid":false,"given":"Samuel","family":"Bennett","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-9845","authenticated-orcid":false,"given":"Alex","family":"Pu","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Annabathula","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diljon","family":"Chahal","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Aalaei\u2010Andabili","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4252-5206","authenticated-orcid":false,"given":"Anuj","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melsjian","family":"Shkullaku","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Vesely","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Benitez","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Strauss","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Mysore","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham","family":"Allaham","sequence":"additional","affiliation":[{"name":"University of Maryland Baltimore School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60692-9"},{"issue":"5","key":"e_1_2_10_4_1","first-page":"e72","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease","volume":"143","author":"Otto C. M.","year":"2021","journal-title":"Circulation"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1806640"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668681"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00337"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.15420\/usc.2021.17"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw096"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194364"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.57"},{"issue":"1","key":"e_1_2_10_13_1","first-page":"61","article-title":"Aortic Stenosis","volume":"38","author":"Ross J.","year":"1968","journal-title":"Circulation"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.07.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1127660"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.051"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.111.967554"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.08.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.043"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.122.025648"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.11.042"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.124.017598"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.01.002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew335"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003071"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.10.015"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.01.045"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007146"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70639","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:15:44Z","timestamp":1786558544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ccd.70639"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70639","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"2025-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}