{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:26Z","timestamp":1785776246315,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the progressively increasing number of low\u2010risk patients undergoing transcatheter aortic valve replacement (TAVR), the number of those who will be long\u2010time pacemaker (PM) carriers is expected to increase. To date, conflicting data is available regarding the association between PM and mortality following TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the association between PM and mortality in patients undergoing TAVR with self\u2010expandable bio\u2010prosthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing TAVR between 2007 and 2014 in 10 Italian centers were considered. Two analyses were performed: one comparing patients with and without pre\u2010TAVR PM (primary) and one comparing those with and without post\u2010TAVR PM (secondary). The primary endpoint was all\u2010cause mortality; the secondary endpoint was re\u2010hospitalization to the cardiac ward. Clinical outcomes were assessed at the longest available follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 1779 patients were included in the primary analysis and 1465 in the secondary one. Pre\u2010TAVR PM implantation was not associated with an increased risk of all cause death in both the primary (adj. HR 0.93, 95% CI 0.76\u22121.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.475) and secondary analysis (adj. HR 0.83, 95% CI 0.71\u22120.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029). Regarding hospitalization to cardiac ward, pre\u2010TAVR PM was not associated with the outcome (adj. HR 1.10, 95% CI 0.85\u22121.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.254), while post\u2010TAVR PM implantation was related with an increased risk (adj. HR 1.94, 95% CI 1.56\u22122.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PM implantation is not associated with an increased risk of mortality in patients undergoing TAVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70652","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:52:04Z","timestamp":1778586724000},"page":"314-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of Pacemaker Implantation in Transcatheter Aortic Valve Replacement With Self\u2010Expanding Prosthesis"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-3006","authenticated-orcid":false,"given":"Francesco De","family":"Felice","sequence":"first","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3290-4053","authenticated-orcid":false,"given":"Luca","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Stefano","family":"Nazzaro","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Musto","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Chin","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Stio","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pennacchi","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Azienda Ospedaliera S. Camillo Forlanini Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-440X","authenticated-orcid":false,"given":"Mauro","family":"Massussi","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory and Cardiology ASST Spedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Chizzolla","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory and Cardiology ASST Spedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Institute of Cardiology ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-9804","authenticated-orcid":false,"given":"Marco De","family":"Carlo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Section, Cardiothoracic and Vascular Department Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Giannini","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Section, Cardiothoracic and Vascular Department Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Costa","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Section, Cardiothoracic and Vascular Department Azienda Ospedaliero\u2010Universitaria Pisana Pisa 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