{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:25Z","timestamp":1785776245050,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical impact of angiography\u2010based, computational pressure\u2010flow dynamics derived FFR (caFFR) after paclitaxel\u2011coated balloon (DCB) angioplasty remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the prognostic value of post\u2010procedural caFFR in the treatment of in\u2010stent restenosis (ISR) with DCB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients undergoing DCB angioplasty for ISR at Xijing Hospital, China, between December 2015 and December 2019 were prospectively enrolled. The primary endpoint was vessel\u2010oriented composite endpoint (VoCE), defined as a composite of vessel\u2010related cardiovascular death, target\u2010vessel myocardial infarction (TV\u2010MI), and ischemia\u2010driven target vessel revascularization (ID\u2010TVR) at 3\u2010year, assessed at the vessel level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1055 vessels treated with DCB were screened, and the post\u2010procedural caFFR was analyzable in 999 (94.7%). At 3\u2010year, 149 VoCE (14.9%) and 98 ID\u2010TVR (9.8%) events occurred. Maximally\u2010selected log\u2010rank statistics respectively identified post\u2010procedural caFFR value of 0.87 and post\u2010procedural %DS of 28 as the optimal cutoff points to predict VoCE. Post\u2010procedural caFFR demonstrates the superior predictive ability for VoCE compared to post\u2010procedural %DS (NRI: 7.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A negative correlation was discerned between post\u2010procedural caFFR value and VoCE (HR\n                      <jats:sub>per 0.1 increase<\/jats:sub>\n                      : 0.72, 95% CI: 0.53\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). Post\u2010procedural caFFR\u2009\u2264\u20090.87 group was associated with a 1.5\u2010fold increase in the risk of VoCE (HR\n                      <jats:sub>IPTW<\/jats:sub>\n                      : 1.53, 95% CI: 1.02\u20132.29) and a 1.8\u2010fold increase in ID\u2010TVR (HR\n                      <jats:sub>IPTW<\/jats:sub>\n                      : 1.82, 95% CI: 1.15\u20132.89).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A higher post\u2010procedural caFFR value is associated with improved vessel\u2010related clinical outcomes in patients of ISR treated by DCB. Achieving a post\u2010procedural caFFR value of 0.87 in the treated vessels may represent a reasonable procedural goal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinicaltrial.gov identifier: NCT05133921<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70653","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:35:47Z","timestamp":1779078947000},"page":"376-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Computational Pressure\u2010Flow Dynamics Derived FFR Measured Immediately After Successful Paclitaxel\u2011Coated Balloon Angioplasty for In\u2010Stent Restenosis Lesion"],"prefix":"10.1002","volume":"108","author":[{"given":"Wangwei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-6470","authenticated-orcid":false,"given":"Xingqiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University Xi'an China"},{"name":"Department of Cardiology University of Galway Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjun","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University Xi'an 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