{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:26Z","timestamp":1785776246309,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early identification and targeted treatment of coronary lesions at higher risk of future events remains a major unmet need in coronary artery disease research. Invasive treatment of such plaques is controversial. The third\u2010generation bioresorbable magnesium scaffold (DREAMS 3G) may provide a valuable alternative, but it has not been evaluated in this setting. The BIOMAG\u2010I study, with comprehensive OCT and IVUS imaging, offers a unique opportunity to investigate high\u2010risk plaque morphology and its vascular response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to assess the association between lesions with high\u2010risk plaque features treated with the DREAMS 3G scaffold and late lumen loss (LLL) at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post\u2010hoc analysis included patients with stable coronary artery disease and high\u2010quality intravascular imaging. High\u2010risk plaque was defined as \u03bcFR\u2009&gt;\u20090.80 with PB\u2009\u2265\u200970%. Subgroups were further stratified by the presence of MLA\u2009&lt;\u20094\u2009mm\u00b2, TCFA\u2009&lt;\u200980 \u03bcm, lipid arc &gt;90\u00b0, or all combined PB was assessed by IVUS or estimated by OCT when IVUS was unavailable. LLL was measured at 6 and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 83 patients, 42 (50.6%) met the definition of \u03bcFR\u2009&gt;\u20090.80 with PB\u2009\u2265\u200970%. Within this cohort, 41 also had MLA\u2009&lt;\u20094\u2009mm\u00b2, 23 had TCFA\u2009&lt;\u200980 \u03bcm, 16 had lipid arc\u2009\u2265\u2009180\u00b0, and 16 presented all four features. LLL remained low in the overall PB\u2009\u2265\u200970% group (0.21\u2009\u00b1\u20090.29\u2009mm at 6 months; 0.27\u2009\u00b1\u20090.44\u2009mm at 12 months) and was similarly low or even lower across the additional subgroups, including those with all features combined (0.19\u2009\u00b1\u20090.21\u2009mm and 0.16\u2009\u00b1\u20090.19\u2009mm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this sub\u2010analysis of the BIOMAG\u2010I trial, the DREAMS 3G bioresorbable magnesium scaffold demonstrated favorable performance, with low LLL and a low rate of clinical outcomes during the resorption period. These findings support DREAMS 3G as a promising \u201cleave\u2010nothing\u2010behind\u201d strategy for selected high\u2010risk plaques, warranting confirmation in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70655","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:39:57Z","timestamp":1780889997000},"page":"568-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Patients With High\u2010Risk Plaques Treated With a Bioresorbable Magnesium Scaffold: Insights From the BIOMAG\u2010I Study"],"prefix":"10.1002","volume":"108","author":[{"given":"Pablo M.","family":"Rubio","sequence":"first","affiliation":[{"name":"Interventional Cardiology Medstar Washington Hospital Center Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M.","family":"Garcia\u2010Garcia","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Medstar Washington Hospital Center Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebremedhin D.","family":"Melaku","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Medstar Washington Hospital Center Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloina","family":"Baltazar","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Antiguo Hospital Civil de Guadalajara Fran Antonio Alcalde, GDL  Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Haude","sequence":"additional","affiliation":[{"name":"Medical Clinic, I Rheinland Klinikum Neuss GmbH, Lukaskrankenhaus Neuss Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Wlodarczak","sequence":"additional","affiliation":[{"name":"Division of Cardiology at the Copper Health Center Inc. Lubin Poland"},{"name":"Faculty of Medicine University of Science and Technology in Wroclaw  Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 J","family":"van der Schaaf","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology OLVG Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Torzewski","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Oberallg\u00e4u\u2010Kempten Kempten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Ferdinande","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost Limburg (ZOL) Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hospital Clinico San Carlos IdISSC, Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Cardiology Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8301-4517","authenticated-orcid":false,"given":"Johan","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor G.","family":"Toth","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[{"name":"Clinical for Cardiology TUM University Hospital German Heart Center, Munich, Germany, and German Center for Cardiovascular Research (DZHK) e.V. Partner Site Munich Heart Alliance  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Toelg","sequence":"additional","affiliation":[{"name":"Cardiology Department Heart Center Segeberger Kliniken Bad Segeberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Wiemer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intensive Care Johannes Wesling University Hospital, Ruhr University Bochum Minden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Olivecrona","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-3453","authenticated-orcid":false,"given":"Paul","family":"Vermeersch","sequence":"additional","affiliation":[{"name":"Interventional Cardiology ZNA Middelheim Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-9226","authenticated-orcid":false,"given":"Ron","family":"Waksman","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Medstar Washington Hospital Center Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.05.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht484"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00326"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00182"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.10.032"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-24-00387"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)00413-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.547"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00628"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.08.336"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001039"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jead299"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-25-00396"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez185"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10111319"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:33:27Z","timestamp":1785774807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,7]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ccd.70655"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70655","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,7]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}