{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:26Z","timestamp":1785776246329,"version":"3.56.0"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Renal denervation (RDN) is a minimally invasive technique that disrupts renal sympathetic nerve activity, reducing sympathetic overdrive implicated in hypertension and other cardiovascular disorders. After early enthusiasm waned following SYMPLICITY HTN\u20103, subsequent rigorously designed trials re\u2010established its efficacy. This review summarizes mechanistic insights, clinical evidence, and emerging applications of RDN. Data from randomized trials, meta\u2010analyses, registries, and translational studies were evaluated to assess their safety, efficacy, and broader therapeutic potential. Recent trials (SPYRAL HTN\u2010OFF MED, RADIANCE HTN\u2010TRIO, RADIANCE II) show consistent and durable systolic blood pressure reductions of approximately 5\u201310\u2009mmHg with excellent safety. Beyond resistant hypertension, preliminary studies suggest benefits in heart failure (HFrEF and HFpEF), atrial fibrillation when combined with pulmonary vein isolation, chronic kidney disease, and metabolic syndrome. Mechanistic data reveal improved autonomic balance, regression of left ventricular hypertrophy, and possible renal protection. Limitations include procedural variability, incomplete nerve ablation, and the lack of large outcome\u2010based cardiovascular trials. Nevertheless, cost\u2010effectiveness analyses and recent ESC (2024) and AHA\/ACC (2025) guidelines endorse RDN as a reasonable adjunct for resistant or uncontrolled hypertension. RDN offers sustained blood pressure control with a strong safety profile. Its expanding role across cardiovascular conditions positions it as a promising adjunctive therapy. Future outcome\u2010driven studies and standardized procedural approaches are needed to refine its place in clinical practice.<\/jats:p>","DOI":"10.1002\/ccd.70656","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:15:53Z","timestamp":1779077753000},"page":"357-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Denervation in Cardiovascular Diseases: Mechanisms, Evidence, and Expanding Applications"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5122-8200","authenticated-orcid":false,"given":"Ameer","family":"Awashra","sequence":"first","affiliation":[{"name":"Department of Medicine An Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroun","family":"Neiroukh","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Alnatour","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Jordan Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada S.","family":"Jibril","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menoufia University Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0873-8374","authenticated-orcid":false,"given":"Mohammed","family":"AbuBaha","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2718-8627","authenticated-orcid":false,"given":"Ahmed","family":"Emara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem","family":"Shehadeh","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7767-6573","authenticated-orcid":false,"given":"Anwar","family":"Zahran","sequence":"additional","affiliation":[{"name":"Department of Medicine An Najah National University Nablus Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-2875","authenticated-orcid":false,"given":"Mohamed S.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tanta University Tanta Gharbia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-0262","authenticated-orcid":false,"given":"Abdalhakim","family":"Shubietah","sequence":"additional","affiliation":[{"name":"Department of Medicine Advocate Illinois Masonic Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-5456","authenticated-orcid":false,"given":"Ali Saad","family":"Al\u2010Shammari","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasar","family":"Sattar","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102196"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.0713"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2016.06.005"},{"key":"e_1_2_18_5_1","doi-asserted-by":"crossref","unstructured":"D.Padmanabhan A.Isath andB. J.Gersh \u201cRenal Denervation: Paradise Lost? Paradise Regained?\u201d (2018) https:\/\/www.uscjournal.com\/articles\/renal-denervation-paradise-lost-paradise-regained?language_content_entity=en.","DOI":"10.15420\/usc.2018.1.2"},{"key":"e_1_2_18_6_1","doi-asserted-by":"crossref","unstructured":"Renal Denervation After USA FDA Approval \u201cAn Update From an Interventional Cardiologist's Perspective [Internet]\u201d (2025) https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3554.","DOI":"10.3390\/jcm14103554"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12191"},{"issue":"19","key":"e_1_2_18_8_1","doi-asserted-by":"crossref","DOI":"10.15420\/ecr.2023.51","article-title":"The Global Burden of Resistant Hypertension and Potential Treatment Options","volume":"19","author":"Buso G.","year":"2024","journal-title":"European Cardiology Review"},{"key":"e_1_2_18_9_1","doi-asserted-by":"crossref","unstructured":"J. J.Noubiap J. R.Nansseu U. F.Nyaga P. S.Sime I.Francis andJ. J.Bigna \u201cGlobal Prevalence of Resistant Hypertension: A Meta\u2010Analysis of Data From 3.2 Million Patients \u201d (January2019) https:\/\/heart.bmj.com\/content\/105\/2\/98.","DOI":"10.1136\/heartjnl-2018-313599"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14554"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00082"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.079889"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12285"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.05.006"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-025-10489-z"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-025-00751-8"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040782"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30554-7"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01598-7"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14103554"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01903-4"},{"key":"e_1_2_18_22_1","article-title":"Renal Denervation Improves Cardiac Function and Exercise Duration in a Miniswine Model of Heart Failure With Preserved Ejection Fraction","author":"Lefer D. J.","year":"2025","journal-title":"European Journal of Heart Failure"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.148.suppl_1.15000"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-022-00658-0"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-023-00857-3"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac189"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0698"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04798"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.23937\/2377-3634\/1410042"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000932"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00788-1"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402670"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2014.15"},{"key":"e_1_2_18_34_1","article-title":"Renal Denervation in the Treatment of Resistant Hypertension","author":"Fulton B.","year":"2022","journal-title":"American College of Cardiology"},{"key":"e_1_2_18_35_1","unstructured":"American College of Cardiology \u201cRADIANCE\u2010HTN TRIO: Renal Denervation Effective Safe in Treatment\u2010Resistant Hypertension [Internet] \u201d (2021) https:\/\/www.acc.org\/Latest-in-Cardiology\/Articles\/2021\/05\/12\/19\/08\/Sun-1045am-RADIANCE-HTN-TRIO-acc-2021."},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.045"},{"key":"e_1_2_18_37_1","article-title":"Truth Is Born in Disputes: The Pros and Cons of Renal Denervation","volume":"22","author":"Mikhail V. I.","year":"2022","journal-title":"ESC Journal of Cardiology Practice"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu209"},{"key":"e_1_2_18_39_1","article-title":"2025 AHA\/ACC\/AANP\/AAPA\/ABC\/ACCP\/ACPM\/AGS\/AMA\/ASPC\/NMA\/PCNA\/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","author":"Jones D. W.","year":"2025","journal-title":"Circulation"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.810321"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01543-6"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2025.10.013"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1010546"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.03.017"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-024-02417-2"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.193870"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu093"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2025.08.012"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04019"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.70805"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14223"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11180"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.027"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000347"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001682"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw325"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.06.044"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001798"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1236-0"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037654"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.06.007"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.70090"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14922"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01659-6"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.11.002"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.10.019"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1210801"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16292"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022429"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003909"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14103554"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000240"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2025.104440"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14945"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.034915"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-025-02406-2"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.125.24749"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:33:26Z","timestamp":1785774806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ccd.70656"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70656","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"2025-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}