{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:05Z","timestamp":1785776225756,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Chronic coronary syndrome (CCS) remains associated with recurrent ischemic symptoms and impaired quality of life despite contemporary guideline\u2010directed medical therapy. Low\u2010dose colchicine has demonstrated prognostic benefits in randomized trials; however, real\u2010world data regarding its effects on functional capacity and angina\u2010related outcomes are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, real\u2010world observational study included 614 patients with CCS receiving low\u2010dose colchicine therapy for secondary prevention. Functional capacity and angina\u2010related quality of life were assessed before and after colchicine treatment using the Seattle Angina Questionnaire. Changes in daily physical activities, angina frequency, nitroglycerin use, treatment satisfaction, and Canadian Cardiovascular Society (CCS) angina class were evaluated. Clinical outcomes and tolerability, including hospitalization, revascularization, and gastrointestinal adverse effects, were also analyzed. A clinically meaningful improvement was defined as a\u2009\u2265\u200910\u2010point increase in the composite Seattle Angina Questionnaire score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the study population was 68.8\u2009\u00b1\u200911.5 years, and 70.5% of patients were male. Following colchicine therapy, significant improvements were observed in functional capacity, including walking on level ground, household activities, and carrying heavy objects (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Angina frequency scores improved, accompanied by reduced nitroglycerin use (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Treatment satisfaction increased and limitations in enjoyment of life decreased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). CCS angina class decreased from 2.61\u2009\u00b1\u20090.7 to 1.4\u2009\u00b1\u20090.62 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A clinically meaningful improvement in SAQ score was observed in 78.7% of patients. During follow\u2010up, hospitalization occurred in 9.0% of patients, revascularization in 4.4%, and gastrointestinal adverse effects were reported in 9.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a multicenter real\u2010world cohort of patients with chronic coronary syndrome, low\u2010dose colchicine therapy was associated with significant improvements in functional capacity, angina severity, and quality of life, with an acceptable safety profile. The high rate of clinically meaningful patient\u2010reported improvement further supports colchicine as an effective adjunctive therapy for secondary prevention and symptom control in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70662","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:04:58Z","timestamp":1779451498000},"page":"395-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Dose Colchicine for Secondary Prevention in Patients With Chronic Coronary Syndrome: A Multicenter Real\u2010World Study"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-6390","authenticated-orcid":false,"given":"Ecem","family":"G\u00fcrses","sequence":"first","affiliation":[{"name":"Department of Cardiology Bak\u0131r\u00e7ay University \u00c7i\u011fli Training and Research Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Do\u011fdu\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology Izmir University of Economics, Medical Point Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-2751","authenticated-orcid":false,"given":"Umut","family":"Uyan","sequence":"additional","affiliation":[{"name":"\u00d6demi\u015f State Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0268-9641","authenticated-orcid":false,"given":"Ahmet","family":"\u00d6z","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Javadova","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6k\u00e7e Nur Durmu\u015f","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"\u00c7abuk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Izmir City Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Sivri","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bak\u0131r\u00e7ay University \u00c7i\u011fli Training and Research Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Zoghi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8312-310X","authenticated-orcid":false,"given":"\u0130lker","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bak\u0131r\u00e7ay University \u00c7i\u011fli Training and Research Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1322"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.06.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021372"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.038"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021993"},{"key":"e_1_2_9_14_1","first-page":"955","article-title":"Inflammation and Coronary Artery Disease","volume":"159","author":"Hsue P. 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