{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:08Z","timestamp":1785776228686,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No head\u2010to\u2010head trials have directly compared GLP\u20101 receptor agonists (GLP\u20111 RAs) and SGLT2 inhibitors (SGLT2is) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare short\u2010, mid\u2010, and long\u2010term clinical outcomes of GLP\u20101 RAs versus SGLT2 inhibitors in adults with AMI undergoing PCI, using a multicenter propensity score\u2010matched real\u2010world cohort from the TriNetX US Collaborative Network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter, retrospective cohort study used de\u2010identified data from the TriNetX US Collaborative Network. Adults with AMI who underwent PCI and initiated either GLP\u20111 RAs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097201) or SGLT2is (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094252) within 14 days were included. One\u2010to\u2010one greedy nearest\u2010neighbor propensity score matching (caliper 0.1) yielded balanced cohorts across &gt;\u200950 covariates, resulting in 1752 patients per group. Kaplan\u2212Meier and Cox models assessed mortality, heart failure, hospitalization, recurrent myocardial infarction (RMI), stroke, atrial fibrillation, major adverse cardiovascular events (MACE), acute kidney injury (AKI), and cardiac arrest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with SGLT2is, GLP\u20101 RAs were associated with lower 1\u2010year risks of acute heart failure (HR 0.415 [0.343\u20130.501]), all\u2010cause hospitalization (HR 0.559 [0.495\u20130.631]), RMI (HR 0.799 [0.710\u20130.899]), stroke (HR 0.800 [0.667\u20130.959]), atrial fibrillation (HR 0.804 [0.693\u20130.932]), MACE (HR 0.788 [0.706\u20130.881]), and AKI (HR 0.534 [0.444\u20130.643]). At 30 days, absolute risk reduction was lower with GLP\u20101 RAs for acute heart failure (7.19% [5.66%\u20138.72%]) and all\u2010cause hospitalization (16.61% [14.24%\u201318.98%]). All\u2010cause mortality did not differ at 30 or 90 days but was lower at 1 year (HR 0.700 [0.507\u22120.967]). Cardiac arrest did not differ significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world, propensity score\u2010matched study of patients with AMI undergoing PCI, GLP\u20101 RA initiation linked to lower risk of short\u2010 and long\u2010term adverse outcomes than SGLT2i. These are observational findings needing confirmation in randomized trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70668","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:56:21Z","timestamp":1780293381000},"page":"511-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of GLP\u20101 RAs Versus SGLT2 Inhibitors in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Multicenter Propensity Score\u2010Matched Real\u2010World Study"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8995-1058","authenticated-orcid":false,"given":"Ibrahim","family":"Khalil","sequence":"first","affiliation":[{"name":"Dhaka Medical College and Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Sarker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Reading Hospital West Reading Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1197-9918","authenticated-orcid":false,"given":"Supoma Ghosh","family":"Ria","sequence":"additional","affiliation":[{"name":"Mugda Medical College and Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3949-9388","authenticated-orcid":false,"given":"Md. Imran","family":"Hossain","sequence":"additional","affiliation":[{"name":"Manikganj Medical College and Hospital Manikganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8306-7571","authenticated-orcid":false,"given":"Mst. Mahmuda","family":"Akter","sequence":"additional","affiliation":[{"name":"Manikganj Medical College and Hospital Manikganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Turzo","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Flushing Hospital Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-6522","authenticated-orcid":false,"given":"A. B. 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