{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:33Z","timestamp":1785776253142,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The EMPIRE I study assessed the early (30 days) safety and efficacy of a new fully repositionable delivery system (IMPERIA) for the commercially available ALLEGRA transcatheter aortic valve in patients with either severe native aortic stenosis or a degenerated surgical bioprosthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To report the final 1\u2010year results of the EMPIRE I study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EMPIRE I is a pre\u2010market, prospective, multi\u2010center, single\u2010arm study conducted at 11 centers in 3 European countries. There were independent data safety and clinical events committees and an independent echocardiographic core laboratory. In this analysis, VARC\u20103 definitions of all clinical endpoints and echocardiographic parameters were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study recruited 121 patients with severe native aortic stenosis and 16 with degenerated surgical bioprosthesis. At 1 year, the incidence of bioprosthetic valve dysfunction in the native population was 5.9%. No patients developed structural valve deterioration or endocarditis, and there were no patients with haemodynamic valve deterioration or bioprosthetic valve failure. In the valve\u2010in\u2010valve sub\u2010group, 2\/14 (14.3%) patients had moderate patient prosthesis mismatch at 30 days with no evidence of new bioprosthetic valve dysfunction at 1 year. In the native population, new permanent pacemaker implantation was 14.3% at 30 days and remained unchanged at 1 year. Cardiovascular mortality was 6.8% in the native population and 0% in the valve\u2010in\u2010valve patients. At 1\u2010year, all\u2010cause mortality was 10.8% (95% CI 6.4%\u221217.8%) in the native aortic stenosis population and 0% in the valve\u2010in\u2010valve patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After 1 year of follow\u2010up, the results of the EMPIRE 1 study show excellent haemodynamic performance, a low rate of bioprosthetic valve dysfunction, and no bioprosthetic valve failure in patients treated with the ALLEGRATM trans\u2010catheter aortic valve implanted using the new IMPERIATM fully repositionable delivery system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70675","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:35:51Z","timestamp":1780292151000},"page":"540-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Echocardiographic Outcomes After Implantation of the ALLEGRA Transcatheter Valve Using the Fully Repositionable IMPERIA Delivery System: One\u2010Year Results of the EMPIRE I Study"],"prefix":"10.1002","volume":"108","author":[{"given":"Jos\u00e9 Antonio","family":"Baz","sequence":"first","affiliation":[{"name":"Servicio de Cardiolog\u00eda Hospital Alvaro Cunqueiro Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire B.","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Cardialysis Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Gef\u00e4\u00dfzentrum Bad Bevensen 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