{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:31Z","timestamp":1785776251317,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare 1\u2010year all\u2010cause mortality and long\u2010term cardiopulmonary outcomes in intermediate\u2010risk pulmonary embolism (PE) treated with mechanical thrombectomy (MT) versus anticoagulation (AC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether MT confers a survival advantage\u2014and whether this benefit differs across intermediate risk PE subgroups remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, 1:1 propensity score\u2013matched cohort study using the TriNetX Analytics Network (2010\u20132026). Adults with acute PE were stratified into low\u2010intermediate (corresponding to AHA\/ACC PE Category C1\u2013C2 in the 2026 AHA\/ACC PE Guideline) and high\u2010intermediate (corresponding to AHA\/ACC PE Category C3) risk subgroups. The primary endpoint was all\u2010cause mortality at 365 days. Secondary endpoints included new\u2010onset pulmonary hypertension, right heart failure, acute respiratory failure, and bleeding. IRB waiver was applicable per HIPAA de\u2010identification standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, 2717 patients per arm were included in the low\u2010intermediate risk cohort and 1150 per arm in the high\u2010intermediate risk cohort. MT was associated with lower 1\u2010year all\u2010cause mortality in both subgroups: low\u2010intermediate risk (11.0% vs. 17.8%; HR 0.642 [95% CI 0.556\u20130.741];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and high\u2010intermediate risk (7.0% vs. 11.0%; HR 0.631 [95% CI 0.475\u20130.839];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). In low\u2010intermediate risk PE, MT was associated with increased pulmonary hypertension (HR 1.578;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and right heart failure (HR 4.473;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In high\u2010intermediate risk PE, MT reduced pulmonary hypertension (HR 0.764;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and bleeding (HR 0.744;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MT was associated with reduced 1\u2010year mortality compared with AC alone in intermediate\u2010risk PE. The net clinical benefit is risk\u2010profile dependent: MT appears favorable in high\u2010intermediate risk (AHA\/ACC Category C3\u2010equivalent) PE, whereas in low\u2010intermediate risk (AHA\/ACC Category C1\u2013C2\u2010equivalent) PE the apparent survival advantage is offset by elevated rates of pulmonary hypertension and right heart failure. These findings are hypothesis\u2010generating and require validation in adequately powered randomized controlled trials with pre\u2010specified long\u2010term mortality endpoints.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70676","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:40:00Z","timestamp":1780292400000},"page":"489-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical Thrombectomy Versus Anticoagulation in Intermediate\u2010Risk Pulmonary Embolism: A Risk\u2010Stratified, Propensity Score\u2013Matched Analysis"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3418-0268","authenticated-orcid":false,"given":"Fouad","family":"Hanna","sequence":"first","affiliation":[{"name":"Faculty of Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdelmaksoud","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of California Riverside California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4310-9686","authenticated-orcid":false,"given":"Ali","family":"Dway","sequence":"additional","affiliation":[{"name":"Al\u2010Andalus University for Medical Sciences Tartus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman","family":"El\u2010Helbawy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Helwan University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Kaelber","sequence":"additional","affiliation":[{"name":"Center for Clinical Informatics Research and Education The MetroHealth System Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-5768","authenticated-orcid":false,"given":"Habib Rehman","family":"Khan","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre Research Institute Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3088-517X","authenticated-orcid":false,"given":"Noha","family":"Hammad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Port\u2010Said University Port\u2010Said Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Mohsen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Loma Linda University Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Basta","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.3.877"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1311-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.055"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1782537"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302097"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5990"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000707"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.12.022"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00732"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2026.1757697"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.125.077232"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.072364"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2021-001856"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001415"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029619853037"},{"key":"e_1_2_11_18_1","first-page":"3004","article-title":"The Post\u2010Pulmonary Embolism Syndrome","volume":"21","author":"Kahn S. 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