{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:34Z","timestamp":1785776254257,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For long coronary lesions, drug\u2010coated balloons (DCBs) might be an attractive alternative compared with drug\u2010eluting stents (DES); however, supporting evidence remains scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy of DCBs versus DES for treating long de novo coronary lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      REC\u2010CAGEFREE I was a non\u2010inferiority trial conducted at 43 sites in China, which randomized 2272 patients to paclitaxel\u2010coated balloon angioplasty with the option of rescue stenting or sirolimus\u2010eluting stents for treating\n                      <jats:italic>de novo<\/jats:italic>\n                      lesions, regardless of vessel diameter. In this pre\u2010specified subgroup analysis, patients were stratified by quantitative coronary angiography\u2010assessed lesion length into short (&lt;\u200920\u2009mm) and long (\u2265\u200920\u2009mm) groups. The primary endpoint was a device\u2010oriented composite endpoint (DoCE, including cardiovascular death, target vessel myocardial infarction, or clinically and physiologically\u2010indicated target lesion revascularization) at 3 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      2,223 (97.8%) participants with available angiograms were included, of which 302 (13.6%) had long lesions and 1921 (86.4%) had short lesions. At 3 years, DoCE occurred in 24\/302 (8.0%) and 121\/1921 (6.3%) patients in long and short groups, respectively. In the long lesions group, DoCE occurred in 14\/121 (11.6%) and 10\/181 (5.6%) in the DCBs and DES groups, respectively (HR\n                      <jats:sub>IPTW<\/jats:sub>\n                      : 2.46, 95% CI: 1.07\u20135.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). In the short lesions group, DoCE occurred in 75\/983 (7.7%) and 46\/938 (4.9%) in the DCBs and DES groups, respectively (HR\n                      <jats:sub>IPTW<\/jats:sub>\n                      : 1.52, 95% CI: 1.03\u20132.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). No significant interaction was observed between lesion length and DES\/DCBs (P\n                      <jats:sub>interaction<\/jats:sub>\n                      \u2009=\u20090.460).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DCBs were associated with a higher risk of DoCE compared to DES for treating de novo lesions, regardless of lesion length.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70679","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:54:38Z","timestamp":1779940478000},"page":"473-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Coated Balloons Versus Drug\u2010Eluting Stents for Patients With Long De Novo Coronary Artery Lesions: Insights From the REC\u2010CAGEFREE I Trial"],"prefix":"10.1002","volume":"108","author":[{"given":"Yuehao","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of Kunming Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1080-3514","authenticated-orcid":false,"given":"Xiongwei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-271X","authenticated-orcid":false,"given":"Yanqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xijing Hospital The Fourth Military Medical University 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