{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:23Z","timestamp":1785776243573,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paravalvular leak (PVL) is a complication after prosthetic valve implantation, leading to issues like hemolysis and heart failure. While redo surgery is the standard treatment, it poses significant risks for high\u2010risk patients. Transcatheter PVL closure has become a less invasive option, with improved efficacy from advanced imaging and device technologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to evaluate the safety, efficacy, and technical strategies of transcatheter PVL closure, including novel approaches like the reverse loop and arteriovenous (AV) rail techniques in a prospective single\u2010center cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight high\u2010risk patients (mean age 57.2\u2009\u00b1\u200910.1 years) with significant aortic or mitral PVLs underwent transcatheter closure. Procedures were guided by multimodal imaging, assessing technical, procedural, and clinical success rates, along with 6\u2010month outcomes in NYHA functional class and echocardiographic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 28 procedures, 27 were technically successful (96.4%), with clinical success achieved in 92.9% of patients. Most procedures used transfemoral access, treating aortic PVLs retrogradely and mitral PVLs through various routes. Advanced techniques like reverse loop (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) and AV rail (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093) were utilized in complex cases. NYHA functional class improved significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with no significant change in left ventricular ejection fraction. One patient required redo surgery, and one died from sepsis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transcatheter PVL closure is a safe and effective alternative to redo surgery for selected high\u2010risk patients. Advanced imaging and access techniques enhance procedural success, particularly in complex mitral PVLs. Further multicenter studies with long\u2010term follow\u2010up are needed to confirm these results and refine technique selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70682","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:01:01Z","timestamp":1780916461000},"page":"578-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter Closure of Paravalvular Leaks: Efficacy, Techniques, and Outcomes From a Single\u2010Center Prospective Study"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-613X","authenticated-orcid":false,"given":"Ehsan","family":"Khalilipur","sequence":"first","affiliation":[{"name":"Cardiovascular Intervention Research Center Rajaie Cardiovascular Institute Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-641X","authenticated-orcid":false,"given":"Ata","family":"Firouzi","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention Research Center Rajaie Cardiovascular Institute Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Elahifar","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention Research Center Rajaie Cardiovascular Institute Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-6687","authenticated-orcid":false,"given":"Mani","family":"Moayerifar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"},{"name":"Department of Cardiovascular Surgery, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seifollah","family":"Abdi","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention Research Center Rajaie Cardiovascular Institute Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Sammak","family":"Salekdeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Anzali International Campus Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-0513","authenticated-orcid":false,"given":"Parham","family":"Sadeghipour","sequence":"additional","affiliation":[{"name":"Vascular Disease and Thrombosis Research Center Rajaie Cardiovascular Medical and Research Institute Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Dabbaghi","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular Medical and Research Center, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Jafari","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Anzali International Campus Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armina Zamani","family":"Kia","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular Medical and Research Center, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Sawaya","sequence":"additional","affiliation":[{"name":"Division of Cardiology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-863X","authenticated-orcid":false,"given":"Mahboobeh","family":"Gholipour","sequence":"additional","affiliation":[{"name":"Cardiovascular Intervention Research Center Rajaie Cardiovascular Institute Tehran Iran"},{"name":"Department of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1290-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx211"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.074"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26961"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8SQA9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.536"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.011"},{"issue":"6","key":"e_1_2_12_9_1","first-page":"350","article-title":"A Comprehensive Review of the Diagnosis and Management of Mitral Paravalvular Leakage","volume":"24","author":"G\u00fcrsoy M. O.","year":"2020","journal-title":"Anatolian Journal of Cardiology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-00581"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.122.012193"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2021.02.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2023.2289714"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2020.07.016"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.11.022"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.10.012"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.31145"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.11.034"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2019.1614706"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:33:07Z","timestamp":1785774787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ccd.70682"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70682","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2025-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}