{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:20:01Z","timestamp":1788268801236,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic inflammation and nutritional status influence outcomes after transcatheter aortic valve replacement (TAVR). The C\u2010reactive protein\u2010albumin\u2010lymphocyte (CALLY) index integrates these domains, but its short\u2010term prognostic value and potential nonlinear associations after TAVR remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the association of baseline CALLY with 30\u2010day all\u2010cause mortality, acute kidney injury (AKI), and stroke after TAVR, and to explore potential nonlinear relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 816 consecutive TAVR patients stratified into low (\n                      <jats:italic>n<\/jats:italic>\n                      = 272), middle (\n                      <jats:italic>n<\/jats:italic>\n                      = 273), and high (\n                      <jats:italic>n<\/jats:italic>\n                      = 271) CALLY tertiles. Outcomes were defined according to Valve Academic Research Consortium\u20103 criteria. Cox models estimated crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Multivariable models were adjusted for age, sex, diabetes, and baseline creatinine. Exploratory piecewise Cox models assessed nonlinearity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within 30 days, 28 patients died (3.4%), 81 developed AKI (9.9%), and 35 experienced stroke (4.3%). Compared with the low tertile, the middle and high tertiles were associated with lower adjusted risks of AKI (middle: HR 0.53, 95% CI 0.31\u20130.90;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.018; high: HR 0.50, 95% CI 0.29\u20130.85;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011). A similar inverse trend was observed for mortality (high vs. low: HR 0.43, 95% CI 0.18\u20131.06; p = 0.066), although statistical significance was not reached. No significant association was observed for stroke. Piecewise modeling demonstrated a significant overall association between CALLY and AKI (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.043), suggesting a nonlinear threshold\u2010type relationship with higher risk concentrated at lower CALLY values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher CALLY values were associated with a lower risk of 30\u2010day AKI after TAVR, with evidence of a nonlinear threshold\u2010type relationship. CALLY may serve as a simple inflammatory\u2013nutritional marker for identifying patients at increased risk of early renal complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70696","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:01:29Z","timestamp":1783922489000},"page":"1064-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the CALLY Index With 30\u2010Day Outcomes After Transcatheter Aortic Valve Replacement"],"prefix":"10.1002","volume":"108","author":[{"given":"Haitham","family":"Abu Khadija","sequence":"first","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot Affiliated with the Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar","family":"Abu Hamdeh","sequence":"additional","affiliation":[{"name":"Palestinian Clinical Research Center Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Masu'd","sequence":"additional","affiliation":[{"name":"Palestinian Clinical Research Center Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duha","family":"Najajra","sequence":"additional","affiliation":[{"name":"Palestinian Clinical Research Center Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Mahamid","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot Affiliated with the Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Bagan","sequence":"additional","affiliation":[{"name":"Adelson School of Medicine Ariel University Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Kirzhner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine A, Kaplan Medical Center and Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majde Abu","family":"Khaled","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot Affiliated with the Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Leviev Cardiothoracic and Vascular Center Sheba Medical Center Tel Hashomer Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Sternik","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Leviev Cardiothoracic and Vascular Center Sheba Medical Center Tel Hashomer Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gera","family":"Gandelman","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot Affiliated with the Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3884-875X","authenticated-orcid":false,"given":"Zeina","family":"Sinnokrot","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot Affiliated with the Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Besharieh","sequence":"additional","affiliation":[{"name":"Heart Center, Kaplan Medical Center, Rehovot Affiliated with the Hebrew University Jerusalem 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