{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:19:54Z","timestamp":1788268794027,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prosthesis\u2010patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) may affect outcomes, but its incidence and impact with contemporary self\u2010expanding valves remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Evaluate the frequency, predictors, and long\u2010term outcomes of PPM in a real\u2010world TAVR population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed patients\u2009\u2265\u200918 years undergoing TAVR with current\u2010generation self\u2010expanding valves (Evolut FX\/FX+, PRO\/PRO+, Navitor, Navitor Vision) from a prospectively maintained institutional database (2017\u20132025). Predicted PPM was defined according to VARC\u20103 criteria, with all\u2010cause mortality and heart failure hospitalization as the primary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2989 patients (median age 80 [75\u221285], 50.8% female) receiving Evolut (83.3%) or Navitor (16.7%) valves, PPM occurred in 5.0% (moderate 3.7%, severe 1.3%) and declined from 6.5% in 2017 to 2.7% in 2025 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Independent predictors of PPM included female sex (OR 2.04, 95% CI 1.06\u22123.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035) and valve\u2010in\u2010valve procedures (OR 9.60, 95% CI 3.82\u221225.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas use of the Navitor valve was associated with markedly lower odds (OR 0.07, 95% CI 0.00\u22120.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Patients with PPM demonstrated significantly higher post\u2010procedural transvalvular gradients and reduced aortic valve areas (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). PPM was not associated with adverse long\u2010term clinical outcomes, with no significant differences in 5\u2010year all\u2010cause mortality (HR 0.84, 95% CI 0.45\u22121.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.592) or heart failure hospitalization (HR 1.22, 95% CI 0.84\u22121.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.295).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this contemporary TAVR cohort, PPM was infrequent, and its incidence declined over time. Female sex and valve\u2010in\u2010valve procedures independently predicted PPM. Despite adverse hemodynamic profiles, PPM was not associated with early or long\u2010term adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70698","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:27:13Z","timestamp":1782127633000},"page":"721-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prosthesis\u2010Patient Mismatch in All\u2010Comer Patients Undergoing Newer\u2010Generation Self\u2010Expanding Transcatheter Aortic Valve Replacement"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-0686","authenticated-orcid":false,"given":"Xander","family":"Jacquemyn","sequence":"first","affiliation":[{"name":"UPMC Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"},{"name":"Department of Cardiothoracic Surgery University of Pittsburgh Pittsburgh 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