{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:57:11Z","timestamp":1785776231696,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It was still unclear whether sex\u2010related differences in the prevalence and clinical outcomes of patients with moderate\u2010to\u2010severe coronary artery calcification (MSCAC) who underwent percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to evaluate sex\u2010related differences in the prevalence and clinical outcomes in patients who underwent MSCAC\u2010PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 10,681 consecutive patients with or without MSCAC from the prospective Fuwai PCI Registry. The primary outcome was the major adverse cardiovascular and cerebrovascular event (MACCE, a composite of cardiovascular death, myocardial infarction, and stroke).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 10,681 patients who underwent PCI, 18.24% of patients had MSCAC. The prevalence of MSCAC was 19.81% in women and 17.99% in men. Before age 62, MSCAC prevalence predominated in men, whereas after age 62, women exhibited higher prevalence. For individuals aged \u2265\u200962 years, females again showed a higher prevalence of MSCAC compared to males (adjusted OR, 1.24; 95% CI, 1.01\u22121.52), and there was no significant difference between sexes in patients aged\u2009&lt;\u200962 years. Among patients with MSCAC, relative to men, women have a higher risk of MACCE (adjusted HR, 2.89; 95% CI, 1.56\u22125.34), primarily coming from the increased risk of cardiovascular death and stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, women with MSCAC faced higher long\u2010term cardiovascular risks compared with men. An age\u2010dependent divergence in MSCAC prevalence was observed, with higher prevalence in women after age 62.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70700","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:12:02Z","timestamp":1781237522000},"page":"610-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010Related Differences in the Prevalence and Clinical Outcomes of Moderate\u2010to\u2010Severe Coronary Artery Calcification in Patients Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-9724","authenticated-orcid":false,"given":"Zhangyu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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