{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:20:02Z","timestamp":1788268802320,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delirium is an underrecognized geriatric complication after transcatheter structural heart interventions, with limited descriptive data across procedures and an uncertain association with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To quantify incidence, identify predictors, and evaluate in\u2011hospital outcomes of delirium after transcatheter aortic valve replacement (TAVR), transcatheter edge\u2010to\u2010edge mitral repair (TEER), transcatheter tricuspid valve replacement\/repair (TTVR), and left atrial appendage occlusion (LAAO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the National Inpatient Sample, we performed a retrospective analysis of adults undergoing TAVR, TEER, TTVR, or LAAO identified by ICD\u201110 codes. Delirium was captured through validated diagnostic codes. Multivariable logistic and linear regression adjusted for demographic, clinical, and in\u2011hospital covariates to evaluate predictors of delirium and the independent association of delirium with clinical outcomes of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 151,455 weighted hospitalizations (86,940 TAVR, 15,305 TEER, 1250 TTVR, and 47,960 LAAO), delirium occurred in 2.8%, 4.0%, 4.4%, and 0.6% of cases, respectively. Delirium was independently associated with increased in\u2010hospital mortality across all procedures (TAVR: aOR 4.5, 95% CI 2.9\u20136.9; TEER: aOR 2.7, 95% CI 1.1\u20136.6; TTVR: aOR 27.7, 95% CI 5.6\u2013137.3; LAAO: aOR 24.5, 95% CI 5.4\u2013110.8). Patients with delirium also had higher rates of mechanical ventilation and cardiac arrest, longer length of stay, and greater hospitalization costs. Geriatric\u2010specific conditions, including frailty, dementia, malnutrition, and high comorbidity burden, were among the strongest predictors of delirium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Delirium after transcatheter structural heart interventions is strongly associated with adverse clinical outcomes and greater resource utilization. These findings underscore the importance of incorporating delirium risk stratification and targeted prevention strategies into structural heart pathways to preserve the net clinical benefit of these interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70709","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:56:30Z","timestamp":1781841390000},"page":"709-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delirium Among Adults Undergoing Transcatheter Structural Heart Intervention: Incidence, Risk, and Clinical Phenotypes"],"prefix":"10.1002","volume":"108","author":[{"given":"Yasser","family":"Jamil","sequence":"first","affiliation":[{"name":"Inova Schar Heart and Vascular Institute Falls Church Virginia 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