{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:19:56Z","timestamp":1788268796761,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pericardial tamponade during atrial fibrillation (AF) ablation is a life\u2010threatening event, yet optimal rescue strategies remain uncertain. This study explored factors influencing rescue duration and long\u2010term outcomes, focusing on the timing of protamine reversal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 3544 consecutive AF ablations (March 2021\u2013April 2025), ten patients who developed acute tamponade were retrospectively analyzed. The primary endpoint was rescue duration, defined as the time from tamponade recognition to patient departure from the electrophysiology (EP) laboratory. Secondary endpoint was a composite of recurrent tamponade, stroke, cardiac rehospitalisation, and all\u2010cause death during follow\u2010up. All patients received protamine and were stratified by median time to further assess its association with rescue duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Protamine administration time correlated positively with rescue duration (Spearman \u03c1\u2009=\u2009+0.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) and remained shorter in the early\u2010use group than in the delay\u2010use group (90 [44\u2013130] vs. 140 [120\u2013172.5] min, directional\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). Lower BMI correlated with longer rescue duration (Spearman \u03c1\u2009=\u2009\u20130.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), and non\u2010paroxysmal AF tended to prolong stabilization. During follow\u2010up, patients with and without secondary endpoint events showed no significant differences in protamine timing, baseline characteristics, AF pattern, or comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Protamine reversal should be considered promptly once pericardial effusion is recognized, as earlier administration may shorten the rescue process and facilitate earlier departure from the EP laboratory without compromising long\u2010term safety. Lower BMI and non\u2010paroxysmal AF were associated with longer rescue durations, suggesting both patient and arrhythmia characteristics may influence rescue complexity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70719","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:36:55Z","timestamp":1783399015000},"page":"966-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Predictors of Rescue Duration in Acute Pericardial Tamponade in Atrial Fibrillation Ablation"],"prefix":"10.1002","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6073-5986","authenticated-orcid":false,"given":"Shenyuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Health Science Center Ningbo University Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1120-6554","authenticated-orcid":false,"given":"Xinzhi","family":"Yu","sequence":"additional","affiliation":[{"name":"Health Science Center Ningbo University Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Health Science Center Ningbo University Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9371-6399","authenticated-orcid":false,"given":"Chenxu","family":"Luo","sequence":"additional","affiliation":[{"name":"Health Science Center Ningbo University Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2613-212X","authenticated-orcid":false,"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Health Science Center Ningbo University Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-6831","authenticated-orcid":false,"given":"Huimin","family":"Chu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caijie","family":"Shen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Feng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Fu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxing","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Jin","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Du","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"},{"name":"Department of Cardiology, Ningbo No. 2 Hospital Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Ningbo University, Ningbo First Hospital Ningbo City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.823179"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.21.2634"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae043"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcab102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy131"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000760"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)74257-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05953.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0689"},{"issue":"1","key":"e_1_2_10_12_1","article-title":"Prevention and Treatment of Pericardial Tamponade in the Electrophysiology Laboratory: A European Heart Rhythm Association Survey","volume":"26","author":"Metzner A.","year":"2023","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-022-02042-x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198503000-00008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001601"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.08.025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.08.012"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283634443"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2025.03.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.02.012"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.70719","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.70719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:44:44Z","timestamp":1788266684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.70719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ccd.70719"],"URL":"https:\/\/doi.org\/10.1002\/ccd.70719","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}