{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:19:54Z","timestamp":1788268794017,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary embolism (PE) remains a leading cause of mortality in the United States. While prior studies show improved outcomes at higher\u2010volume centers, the understanding of procedural utilization remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Therefore, this study aimed to evaluate the association of hospital PE volume and intervention utilization with clinical and financial outcomes in adult patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All non\u2010elective adults (\u226518 years) admitted for PE were identified using the 2016\u20132022 National Inpatient Sample. Annual PE admissions and intervention (mechanical thrombectomy, catheter\u2010directed thrombolysis) caseloads were calculated for each facility. Centers were stratified by PE volume tertiles and classified as low\u2010 (LVH), medium\u2010 (MVH), and high\u2010volume hospitals (HVH). Outcomes included in\u2010hospital mortality, complications, length of stay, and inpatient costs. Multivariable regression and mixed\u2010effect models were used to evaluate associations between hospital PE volume, intervention utilization, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of an estimated 1,475,860 PE hospitalizations, 12.4% and 57.2% were treated at LVH and HVH, respectively. Compared with HVH, LVH had higher unadjusted in\u2010hospital mortality (10.7 vs. 6.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher rates of cardiac and respiratory complications, while undergoing fewer interventions (5.2 vs. 7.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Following risk adjustment, LVH remained associated with increased odds of in\u2010hospital mortality (AOR 2.08, 95% CI 1.99\u20132.17), cardiac (AOR 1.16, 95% CI 1.09\u20131.24), and respiratory complications (AOR 1.11, 95% CI 1.07\u20131.14), and lower odds of receiving intervention (AOR 0.68, 95% CI 0.64\u20130.73). Higher institutional PE volume and intervention utilization were each independently associated with reduced mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Notably, increasing PE volume mitigated differences in mortality associated with intervention utilization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower hospital PE volume was associated with higher mortality and complications. Additionally, intervention utilization was positively correlated with institutional PE caseload. Of note, higher PE admission volume was associated with improved outcomes regardless of treatment strategy. These findings suggest institutional experience may play a key role in high\u2010quality PE care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70724","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:42:46Z","timestamp":1783327366000},"page":"890-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Hospital Volume With Outcomes of Pulmonary Embolism in the United States"],"prefix":"10.1002","volume":"108","author":[{"given":"Zihan","family":"Gao","sequence":"first","affiliation":[{"name":"Cardiovascular Outcomes Research Laboratories (CORELAB) University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy N.","family":"Coaston","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Laboratories (CORELAB) University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Hinks","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Laboratories (CORELAB) University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Qadir","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obi","family":"Emeruwa","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1867-4361","authenticated-orcid":false,"given":"Peyman","family":"Benharash","sequence":"additional","affiliation":[{"name":"Cardiovascular Outcomes Research Laboratories (CORELAB) University of California Los Angeles Los Angeles California USA"},{"name":"Division of Cardiac Surgery, Department of Surgery University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.16815"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2022.03.060"},{"key":"e_1_2_11_4_1","first-page":"195","volume-title":"Thrombosis and Embolism: From Research to Clinical Practice","author":"Goktay A. 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