{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:15:58Z","timestamp":1784200558630,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>While drug\u2010eluting treatment is a first\u2010line therapy for femoropopliteal (FP) lesions, long\u2010term comparative data between drug\u2010eluting stents (DES) and drug\u2010coated balloons (DCB) in real\u2010world practice are scarce. We aimed to compare the 3\u2010year outcomes of DES versus DCB for symptomatic FP disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of the CILANTRO study, a multicenter registry combining data from the CAPSICUM, POPCORN, and POPCORN Type R studies. Patients treated with either DES or DCB for symptomatic FP lesions were included. To minimize selection bias, we performed 1:1 propensity score matching. The primary outcome was clinically driven target lesion revascularization (TLR), while secondary outcomes included restenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2651 patients treated with DCB and 972 with DES were identified. Propensity score matching extracted 912 pairs with well\u2010balanced baseline characteristics. The median follow\u2010up period was 31.6 months. The 3\u2010year rate of TLR was not significantly different between the DCB and DES groups (23.3% vs. 18.8%; hazard ratio, 1.19 [95% confidence interval, 0.93\u20131.53];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.16). Interaction analysis revealed that a more marked increased risk of TLR in the DCB group in patients with semi\u2010compliant balloon use or without non\u2010compliant balloon use (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017 and 0.018). The 3\u2010year rate of restenosis was significantly higher in the DCB group than in the DES group (38.1% vs. 26.3%; hazard ratio, 1.77 [1.43\u20132.19];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this propensity score\u2010matched analysis, the 3\u2010year rate of TLR was not significantly different between DCB and DES, although DES demonstrated lower restenosis rate. Nevertheless, DCB remains a clinically viable option, and our sub\u2010analysis suggests that balloon selection for pre\u2010dilatation may influence its efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.70750","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:53:26Z","timestamp":1784199206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Coated Balloon Versus Drug\u2010Eluting Stent for Femoropopliteal Lesions: A 3\u2010Year Propensity Score\u2010Matched Analysis"],"prefix":"10.1002","author":[{"given":"Osamu","family":"Iida","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Osaka Keisatsu Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine Osaka University Graduate School of Medicine Suita Japan"},{"name":"Department of Laboratory Medicine The University of Osaka Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-5769","authenticated-orcid":false,"given":"Yoshimitsu","family":"Soga","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8939-0222","authenticated-orcid":false,"given":"Yusuke","family":"Tomoi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizo","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morinomiya Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kishiwada Tokushukai Hospital Kishiwada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-3625","authenticated-orcid":false,"given":"Amane","family":"Kozuki","sequence":"additional","affiliation":[{"name":"Division of Cardiology Osaka Saiseikai Nakatsu Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1436","authenticated-orcid":false,"given":"Akiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sendai Kousei Hospital Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Takatsu General Hospital Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Tobita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shonan Kamakura General Hospital Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terutoshi","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Matsuyama Red Cross Hospital Matsuyama Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Ichihashi","sequence":"additional","affiliation":[{"name":"Division of Radiology Nara Medical University Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CILANTRO investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae179"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.034"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.039"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.057"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.03.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.01.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025677"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/15266028241292464"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.036"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2025.07.034"}],"container-title":["Catheterization and Cardiovascular 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